INF2 and COA8

		INF2	COA8
Description		inverted formin 2	cytochrome c oxidase assembly factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Actin Filament Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Membrane Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Mitochondrial Fission	Response To Reactive Oxygen Species Apoptotic Process Mitochondrial Cytochrome C Oxidase Assembly Protein Stabilization Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		3 interacting genes: BDKRB2 CSNK2A1 UBE2R2
Entrez ID		64423	84334
HPRD ID		08648	12637
Ensembl ID		ENSG00000203485	ENSG00000256053
Uniprot IDs		Q27J81	A0A6Q8JUI0 G3V4L6 Q96IL0
PDB IDs		8RV2 9AZ4 9AZP 9AZQ 9B03 9B0K 9FJN 9FJW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Bradykinin Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Type 1 Angiotensin Receptor Binding Protein Stabilization Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Matrix Side Of Mitochondrial Inner Membrane Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Response To Osmotic Stress Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Protein Stability Regulation Of Response To Osmotic Stress MRNA Methylguanosine-cap Decapping Intracellular Signal Transduction Arachidonate Secretion Response To Salt Stress RNA Decapping Mitochondrial Cytochrome C Oxidase Assembly Regulation Of Cellular Response To Stress Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Sin3-type Complex Respiratory Chain Complex IV Assembly Execution Phase Of Apoptosis Protein Localization To Site Of Double-strand Break PcG Protein Complex Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body
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