NFE4 and MEPCE

		NFE4	MEPCE
Description		nuclear factor, erythroid 4	methylphosphate capping enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Protein-containing Complex	Nucleus 7SK SnRNP Ribonucleoprotein Complex
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding Protein Homodimerization Activity DNA-binding Transcription Factor Binding	RNA Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity SnRNA Binding 7SK SnRNA Binding RNA 5'-gamma-phosphate Methyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II RNA Methylation SnRNA Metabolic Process Methylation SnRNA Modification Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: HDAC1 KAT2B TFCP2	2 interacting genes: ERBB2 RN7SK
Entrez ID		58160	56257
HPRD ID		19326	07889
Ensembl ID		ENSG00000230257	ENSG00000146834
Uniprot IDs			Q7L2J0
PDB IDs			5UNA 6DCB 6DCC 7SLP 7SLQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition RNA 5'-gamma-phosphate Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Krueppel-associated Box Domain Binding Histone Deacetylase Binding Chromatin Remodeling Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity Set3 Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Rpd3L-Expanded Complex Regulation Of Cell Cycle Process Protein Lysine Delactylase Activity Fungiform Papilla Formation N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Decrotonylase Activity Histone Decrotonylase Activity DNA-binding Transcription Factor Binding Chromatin Organization Negative Regulation Of Ribosome Biogenesis Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Hair Follicle Placode Formation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Cell Growth ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Demethylase Activity DNA N6-methyladenine Demethylase Activity Midbody Broad Specificity Oxidative DNA Demethylase Activity Cleavage Furrow Ingression Protein Demethylase Activity Membrane Invagination Engulfment Of Target By Autophagosome 7SK SnRNP
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