PTS and DDX10

		PTS	DDX10
Description		6-pyruvoyltetrahydropterin synthase	DEAD-box helicase 10
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Nucleolus Cytoplasm
	Molecular Function	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Lyase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Tetrahydrobiopterin Metabolic Process	RRNA Processing Anterior Head Development
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Mycophenolate mofetil Biopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)	Bipolar disorder ( 34099189) Femur bone mineral density x serum urate levels interaction ( 34046847) Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)
Interacting Genes		11 interacting genes: AP2M1 COIL DDIT4L FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10	4 interacting genes: APP FBXO7 RNF10 SIRPA
Entrez ID		5805	1662
HPRD ID		11840	03138
Ensembl ID		ENSG00000150787	ENSG00000178105
Uniprot IDs		Q03393	Q13206
PDB IDs		3I2B	2PL3
Enriched GO Terms of Interacting Partners?			Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of System Process Lipoprotein Particle Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Regulation Of Nitric Oxide Metabolic Process Insulin-like Growth Factor Binary Complex Maintenance Of Protein Location In Nucleus Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location Maintenance Of Protein Location In Cell 6-pyruvoyltetrahydropterin Synthase Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Symbiont-mediated Suppression Of Host Innate Immune Response SCF Ubiquitin Ligase Complex GTPase Regulator Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Carotene Metabolic Process Xanthophyll Catabolic Process Zeaxanthin Catabolic Process Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Lutein Catabolic Process Beta,beta-carotene-9',10'-cleaving Oxygenase Activity Carotene Catabolic Process Xanthophyll Metabolic Process Lycopene Catabolic Process Cellular Response To Interleukin-12 PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Maintenance Of Location In Cell Maintenance Of Location
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