ZBTB26 and CYP2W1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZBTB26	CYP2W1
Gene Name		zinc finger and BTB domain containing 26	cytochrome P450, family 2, subfamily W, polypeptide 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytoplasm	Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cell Surface Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function DNA Binding Metal Ion Binding	Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Biological_process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Exogenous Drug Catabolic Process Aflatoxin B1 Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Miscellaneous substrates Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CYP2W1 EIF6 GIPC2 PBK SUMO1 SUMO1P1 UBE2I ZBTB6	2 interactors: CYB5A ZBTB26
Entrez ID		57684	54905
HPRD ID		15692	07901
Ensembl ID		ENSG00000171448	ENSG00000073067
Uniprot IDs		Q9HCK0	Q8TAV3
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Aflatoxin B1 Metabolic Process Positive Regulation Of SUMO Transferase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PML Body Organization Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Mature Ribosome Assembly Protein Localization To Nuclear Pore Protein Localization To Nuclear Envelope Peptidyl-lysine Modification Ribosomal Subunit Export From Nucleus Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic Nuclear Division Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toxin Metabolic Process Regulation Of Protein Catabolic Process Exogenous Drug Catabolic Process Regulation Of Interferon-gamma-mediated Signaling Pathway Drug Catabolic Process Regulation Of Response To Interferon-gamma Ribosomal Large Subunit Biogenesis Organelle Organization
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