ALPK3 and CPEB1

		ALPK3	CPEB1
Description		alpha kinase 3	cytoplasmic polyadenylation element binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Translation Regulator Activity Metal Ion Binding
	Biological Process	Heart Development Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Development	MRNA Processing Translation Regulation Of Translation Negative Regulation Of Translation Regulation Of MRNA 3'-end Processing Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Stimulus Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translation
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Alzheimer's disease (age of onset) ( 22005931) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Metabolite levels ( 23823483) P wave terminal force ( 28794112) PR interval ( 32439900) Schizophrenia ( 29483656)	Age at first sexual intercourse ( 34211149) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) General cognitive ability ( 29844566) Schizophrenia ( 28991256 30285260) Tourette syndrome ( 30818990)
Interacting Genes			9 interacting genes: APP AURKA DYNLRB1 EIF4E KIF1B MAP2 PIN1 SLC16A7 SNCA
Entrez ID		57538	64506
HPRD ID		11365	09553
Ensembl ID		ENSG00000136383	ENSG00000214575
Uniprot IDs		Q96L96	A0A087WXG7 B4DWY2 Q9BZB8
PDB IDs			2M13 2MKE 2MKH 2MKK 2N1O
Enriched GO Terms of Interacting Partners?			Main Axon Tau Protein Binding Microtubule-based Process Axon Hillock Postsynapse Negative Regulation Of Microtubule Polymerization Positive Regulation Of Mitotic Cell Cycle Regulation Of Presynapse Organization Neuron Projection Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Molecular Function Activator Activity Regulation Of Neurotransmitter Uptake Cellular Response To Copper Ion Microtubule Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Response To Copper Ion Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Presynapse Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Mitotic Cell Cycle Dendrite Development Eukaryotic Initiation Factor 4G Binding Glutamatergic Synapse Apical Distal Dendrite Negative Regulation Of Microtubule Polymerization Or Depolymerization Cis-trans Isomerase Activity Cytoskeletal Motor Activity Phosphoprotein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Synaptic Vesicle Transport Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Kinesin Binding Pyruvate Secondary Active Transmembrane Transporter Activity Regulation Of Neuronal Synaptic Plasticity Synapse Organization Microtubule Binding Microtubule Motor Activity Regulation Of Microtubule-based Process
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