PSPH and ITGB8

		PSPH	ITGB8
Description		phosphoserine phosphatase	integrin subunit beta 8
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta8 Complex Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Hydrolase Activity L-phosphoserine Phosphatase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Integrin Binding Metal Ion Binding Extracellular Matrix Protein Binding
	Biological Process	In Utero Embryonic Development L-serine Metabolic Process L-serine Biosynthetic Process Amino Acid Biosynthetic Process Response To Mechanical Stimulus Response To Nutrient Levels Response To Testosterone	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Cell-cell Adhesion
Pathways		Serine metabolism	Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs
Drugs		Zinc 3-Phosphono-D-alanine Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Estimated glomerular filtration rate ( 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 30837465 31070104) Macular telangiectasia type 2 ( 28250457 33654266) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma homocysteine levels (post-methionine load test) ( 24651765) Serum metabolite levels ( 33031748)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 34103634 31959851 31619474 31361310 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil count ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Type 1 diabetes ( 34012112) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: ATXN1 UBC	6 interacting genes: DYRK1A ITGAV PPP1CA PPP1R9B TGFB1 VTN
Entrez ID		5723	3696
HPRD ID		01406	05001
Ensembl ID		ENSG00000146733	ENSG00000105855
Uniprot IDs		P78330	P26012 Q9BUG9
PDB IDs		1L8L 1L8O 1NNL 6HYJ 6HYY 6Q6J	6DJP 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8TCF 8VS6 8VSD 9IND
Enriched GO Terms of Interacting Partners?			Histone H3T45 Kinase Activity Semicircular Canal Formation Entry Into Host Cell By A Symbiont-containing Vacuole Endodermal Cell Differentiation Extracellular Matrix Binding Opsonin Binding Cell Adhesion Mediated By Integrin Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Complex Response To Ketone L-phosphoserine Phosphatase Activity Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Liver Regeneration Regulation Of Exit From Mitosis Response To Immobilization Stress Cellular Response To Acetaldehyde Symbiont-containing Vacuole Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Animal Organ Regeneration Inner Ear Development Regulation Of Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining
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