PSMD8 and RPS19

		PSMD8	RPS19
Description		proteasome 26S subunit, non-ATPase 8	ribosomal protein S19
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Lid Subcomplex Proteasome Accessory Complex Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Fibroblast Growth Factor Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Ribosomal Small Subunit Assembly Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cytoplasmic Translation Monocyte Chemotaxis RRNA Processing Translation Nucleolus Organization Erythrocyte Differentiation Maturation Of SSU-rRNA Killing Of Cells Of Another Organism Ribosomal Small Subunit Biogenesis Defense Response To Gram-negative Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		HDL cholesterol levels ( 32203549)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: GLP1R GSK3A GSK3B MTNR1B PRDX6 SHC3 SMAD2 SMAD9 UBC UCHL5	7 interacting genes: APP C5AR1 FGF2 GSK3A RPS19BP1 SPG21 TXNDC11
Entrez ID		5714	6223
HPRD ID		10171	04591
Ensembl ID		ENSG00000099341	ENSG00000105372
Uniprot IDs		P48556 V9HW09	B0ZBD0 P39019
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQA 7QP6 7QP7 7R4X 7TQL 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Tau Protein Binding Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cellular Response To Interleukin-3 SMAD Protein Complex Regulation Of Type B Pancreatic Cell Development Heteromeric SMAD Protein Complex Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Beta-catenin Destruction Complex Protein Kinase A Catalytic Subunit Binding I-SMAD Binding Tau-protein Kinase Activity Ubiquitin Protein Ligase Binding Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway SMAD Protein Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Membrane Permeability Negative Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Metabolic Process Negative Regulation Of Multicellular Organismal Process Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Oxidized DNA Binding Regulation Of Proteasomal Protein Catabolic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of RNA Metabolic Process Glycogen Metabolic Process Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Superior Temporal Gyrus Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Homomeric SMAD Protein Complex Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Protein ADP-ribosylation	Collateral Sprouting Chemoattractant Activity Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Neuron Maturation Astrocyte Activation Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Leukocyte Activation Involved In Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Chemotaxis Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Developmental Growth Regulation Of Carbohydrate Catabolic Process Macrophage Activation Regulation Of ERK1 And ERK2 Cascade Amylin Binding Chemotaxis Positive Regulation Of Toll Signaling Pathway Locomotion Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Heart Growth Negative Regulation Of UDP-glucose Catabolic Process Regulation Of MiRNA Transcription Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mononuclear Cell Migration Regulation Of MiRNA Metabolic Process Positive Regulation Of Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Response To Wortmannin Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Inner Ear Receptor Cell Differentiation Regulation Of Organ Growth Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity
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