KLHL4 and RPL36

		KLHL4	RPL36
Description		kelch like family member 4	ribosomal protein L36
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Ciliary Basal Body	Nucleolus Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Ribonucleoprotein Complex
	Molecular Function	Actin Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Cytoplasmic Translation Translation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644)
Interacting Genes		2 interacting genes: DSCAM GIT1	4 interacting genes: APP DUX4 PTEN RPL18A
Entrez ID		56062	25873
HPRD ID		02283	10201
Ensembl ID		ENSG00000102271	ENSG00000130255
Uniprot IDs		A5PKX1 Q9C0H6	Q9Y3U8
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QGG 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Dendritic Spine Development Protein Tyrosine Kinase Binding Cell Recognition Growth Cone Synapse Negative Regulation Of ARF Protein Signal Transduction Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Locomotory Behavior Structural Constituent Of Postsynaptic Specialization Synapse Organization Positive Regulation Of Axon Extension Involved In Axon Guidance Intramembranous Ossification Motor Learning Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation Regulation Of Phosphorus Metabolic Process Eye Photoreceptor Cell Differentiation Dendrite Photoreceptor Cell Differentiation Cell Junction Organization Positive Regulation Of Receptor Catabolic Process Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Regulation Of ARF Protein Signal Transduction Immunological Synapse Formation Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Glycolytic Process Regulation Of Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding Inhibitory Synapse Calyx Of Held Postsynaptic Density Organization Synaptic Vesicle Recycling Postsynaptic Specialization Organization Negative Regulation Of ATP Metabolic Process Retina Layer Formation Maintenance Of Synapse Structure Excitatory Synapse Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Microtubule Polymerization Gamma-tubulin Binding Cell-cell Adhesion Mediator Activity Positive Regulation Of Axon Extension Mitotic Spindle Pole	Ruffle Membrane Negative Regulation Of Cell Population Proliferation Cell Projection Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Reproductive Process Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Modulation Of Excitatory Postsynaptic Potential Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Reproductive Behavior Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Phagosome Membrane Cold Acclimation
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