KLHL4

Description		kelch like family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Ciliary Basal Body
	Molecular Function	Actin Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644)
Novel Interacting Genes		1 novel interacting genes: RPL36
Interacting Genes		2 interacting genes: DSCAM GIT1
Entrez ID		56062
HPRD ID		02283
Ensembl ID		ENSG00000102271
Uniprot IDs		A5PKX1 Q9C0H6
PDB IDs
Enriched GO Terms of Interacting Partners?		Dendritic Spine Development Protein Tyrosine Kinase Binding Cell Recognition Growth Cone Synapse Negative Regulation Of ARF Protein Signal Transduction Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Locomotory Behavior Structural Constituent Of Postsynaptic Specialization Synapse Organization Positive Regulation Of Axon Extension Involved In Axon Guidance Intramembranous Ossification Motor Learning Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation Regulation Of Phosphorus Metabolic Process Eye Photoreceptor Cell Differentiation Dendrite Photoreceptor Cell Differentiation Cell Junction Organization Positive Regulation Of Receptor Catabolic Process Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Regulation Of ARF Protein Signal Transduction Immunological Synapse Formation Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Glycolytic Process Regulation Of Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding Inhibitory Synapse Calyx Of Held Postsynaptic Density Organization Synaptic Vesicle Recycling Postsynaptic Specialization Organization Negative Regulation Of ATP Metabolic Process Retina Layer Formation Maintenance Of Synapse Structure Excitatory Synapse Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Microtubule Polymerization Gamma-tubulin Binding Cell-cell Adhesion Mediator Activity Positive Regulation Of Axon Extension Mitotic Spindle Pole
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