KCNQ1DN and AP2A2

		KCNQ1DN	AP2A2
Description		KCNQ1 downstream neighbor	adaptor related protein complex 2 subunit alpha 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Presynapse Postsynapse Ficolin-1-rich Granule Membrane
	Molecular Function	Molecular_function	Protein Binding Lipid Binding Kinase Binding Protein Kinase Binding Protein Domain Specific Binding Clathrin Adaptor Activity Disordered Domain Specific Binding
	Biological Process	Biological_process	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways			Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Malaria ( 31844061) Plateletcrit ( 27863252)	Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes			18 interacting genes: AMPH ANXA1 AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC
Entrez ID		55539	161
HPRD ID		17174	06256
Ensembl ID		ENSG00000237941	ENSG00000183020
Uniprot IDs			O94973
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Neurotransmitter Receptor Internalization Clathrin Adaptor Complex AP-2 Adaptor Complex Clathrin Adaptor Activity Endolysosome Membrane Disordered Domain Specific Binding Membrane Coat Clathrin-dependent Endocytosis Clathrin-coated Endocytic Vesicle Synaptic Vesicle Endocytosis Presynaptic Endocytosis Endocytic Vesicle Membrane Ficolin-1-rich Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Vesicle-mediated Transport In Synapse Secretory Granule Membrane Kinase Binding Cytoplasmic Side Of Plasma Membrane Receptor-mediated Endocytosis Protein Domain Specific Binding Presynapse Postsynapse Lipid Binding Endocytosis Protein Kinase Binding	Clathrin-coated Pit Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Receptor-mediated Endocytosis Phospholipid Binding Clathrin Coat Assembly Extrinsic Component Of Presynaptic Endocytic Zone Membrane Cytoplasmic Vesicle Vesicle-mediated Transport In Synapse Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptic Vesicle Regulation Of Endocytosis Early Endosome Clathrin-coated Vesicle Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Clathrin-dependent Endocytosis Synapse Regulation Of Receptor-mediated Endocytosis Cellular Response To Growth Factor Stimulus Endosome Postsynaptic Neurotransmitter Receptor Internalization Response To Growth Factor Plasma Membrane Postsynaptic Endocytic Zone Cytoplasmic Vesicle Membrane Intracellular Transport Clathrin Heavy Chain Binding Vesicle Regulation Of Transport AP-2 Adaptor Complex Organelle Organization Presynapse Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Clathrin Adaptor Activity Regulation Of Multicellular Organismal Development Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Cellular Component Organization Cellular Localization Negative Regulation Of Blood Circulation Regulation Of Developmental Process Insulin Receptor Binding Membrane Regulation Of Cellular Component Organization Positive Regulation Of Transport Membrane Coat Chemical Synaptic Transmission
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