PPT1 and RLF

		PPT1	RLF
Description		palmitoyl-protein thioesterase 1	RLF zinc finger
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Synaptic Vesicle Membrane Axon Dendrite Synaptic Vesicle Membrane Neuronal Cell Body Lysosomal Lumen Membrane Raft Extracellular Exosome Presynaptic Cytosol	Nucleus
	Molecular Function	Protein Binding Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity Phospholipase A2 Inhibitor Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Palmitoyl Hydrolase Activity Sulfatide Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Depalmitoylation Endocytosis Receptor-mediated Endocytosis Pinocytosis Lysosome Organization Lysosomal Lumen Acidification Neurotransmitter Secretion Nervous System Development Brain Development Visual Perception Grooming Behavior Associative Learning Adult Locomotory Behavior Macromolecule Catabolic Process Protein Transport Lipid Catabolic Process Sphingolipid Catabolic Process Protein Catabolic Process Negative Regulation Of Cell Growth Membrane Raft Organization Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Pinocytosis Neuron Development Regulation Of Synapse Structure Or Activity	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Heterochromatin Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Fatty acyl-CoA biosynthesis
Drugs		Hexadecanesulfonyl fluoride Palmitic Acid
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Blood protein levels ( 30072576) Platelet count ( 32888494)	High density lipoprotein cholesterol levels ( 30498476) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		2 interacting genes: GNAQ LCOR	7 interacting genes: CLK1 FBXL17 GCH1 PRPF40A RIT1 RIT2 TRIM14
Entrez ID		5538	6018
HPRD ID		07203	01614
Ensembl ID		ENSG00000131238	ENSG00000117000
Uniprot IDs		P50897 Q5T0S4	Q13129
PDB IDs		3GRO
Enriched GO Terms of Interacting Partners?			GTPase Activity GTP Cyclohydrolase I Activity GTP Binding GDP Binding G Protein Activity Ras Protein Signal Transduction
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