DNAAF2 and L2HGDH

		DNAAF2	L2HGDH
Description		dynein axonemal assembly factor 2	L-2-hydroxyglutarate dehydrogenase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Cilium Ciliary Basal Body Protein Folding Chaperone Complex Dynein Axonemal Particle	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding	Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors 2-hydroxyglutarate Dehydrogenase Activity
	Biological Process	In Utero Embryonic Development Epithelial Cilium Movement Involved In Extracellular Fluid Movement Response To Retinoic Acid Outer Dynein Arm Assembly Inner Dynein Arm Assembly Protein Stabilization Establishment Of Localization In Cell Cilium-dependent Cell Motility Establishment Of Left/right Asymmetry Axonemal Dynein Complex Assembly	2-oxoglutarate Metabolic Process Small Molecule Metabolic Process
Pathways			Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Carotid intima media thickness ( 26343869)	Estimated glomerular filtration rate ( 31015462 31152163 31451708) Liver enzyme levels (alanine transaminase) ( 33972514) Periodontal disease-related phenotype (Socransky) ( 24347629) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30224653)
Interacting Genes		3 interacting genes: APP HMGB1 RNF10	1 interacting genes: SLC25A21-AS1
Entrez ID		55172	79944
HPRD ID		12627	12640
Ensembl ID		ENSG00000165506	ENSG00000087299
Uniprot IDs		Q9NVR5	Q9H9P8
PDB IDs
Enriched GO Terms of Interacting Partners?		RAGE Receptor Binding Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Positive Regulation Of Interleukin-1 Production Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Chemoattractant Activity Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Monocyte Chemotaxis Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Endoplasmic Reticulum Subcompartment 2-hydroxyglutarate Dehydrogenase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Type II Interferon Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Receptor Ligand Activity Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Myeloid Leukocyte Activation Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Microglia Development	Corticospinal Tract Morphogenesis Ciliary Basal Body Centriolar Subdistal Appendage Ciliary Transition Fiber Microtubule Nucleation By Microtubule Organizing Center Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Establishment Of Left/right Asymmetry Microtubule Anchoring At Centrosome Centriole-centriole Cohesion Microtubule Minus-end Binding Microtubule Anchoring At Microtubule Organizing Center Collateral Sprouting Dynein Axonemal Particle Outer Dynein Arm Assembly Inner Dynein Arm Assembly Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Protein Folding Chaperone Complex Mitotic Spindle Pole Microtubule-based Process Axonemal Dynein Complex Assembly Epithelial Cilium Movement Involved In Extracellular Fluid Movement Nucleolus Extracellular Transport Cytoplasmic Microtubule
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