ZCWPW1 and KMT2E

		ZCWPW1	KMT2E
Description		zinc finger CW-type and PWWP domain containing 1	lysine methyltransferase 2E (inactive)
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GO Annotations	Cellular Component	Nucleus Chromosome	Chromatin Euchromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Membrane Nuclear Body Nuclear Speck Protein-containing Complex Set3 Complex Rpd3L-Expanded Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3 Methyltransferase Activity
	Biological Process	Meiosis I Homologous Chromosome Pairing At Meiosis Spermatogenesis Cell Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair	Neutrophil Mediated Immunity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Erythrocyte Differentiation Epigenetic Regulation Of Gene Expression Neutrophil Activation Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Brain morphology (MOSTest) ( 32665545) Family history of Alzheimer's disease ( 30617256) Hemoglobin levels ( 32327693) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		3 interacting genes: L3MBTL3 MEOX2 VAC14	6 interacting genes: ASH2L ATP13A1 CDCA8 CDK1 CRK LAMTOR5
Entrez ID		55063	55904
HPRD ID		15706	10528
Ensembl ID		ENSG00000078487	ENSG00000005483
Uniprot IDs		A0A804HK41 Q9H0M4	Q8IZD2
PDB IDs		2E61 2RR4	2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?		PAS Complex Set3 Complex Rpd3L-Expanded Complex Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Methylation-dependent Protein Binding Somite Specification Myeloid Cell Differentiation Presynaptic Endosome	Organelle Organization Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Spindle Microtubules To Kinetochore Organelle Assembly Spindle Midzone Positive Regulation Of Chromosome Segregation Protein-containing Complex Pronuclear Fusion Spindle Cytoskeleton Organization DNA N6-methyladenine Demethylase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Mitotic DNA-templated DNA Replication Cellular Component Assembly Cyclin B1-CDK1 Complex Cilium Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Helper T Cell Diapedesis Positive Regulation Of Intracellular Signal Transduction Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Small GTPase Mediated Signal Transduction Linoleic Acid Epoxygenase Activity Epigenetic Regulation Of Gene Expression Positive Regulation Of ARF Protein Signal Transduction Cleavage Furrow Ingression Intracellular Protein Localization Response To Activity Regulation Of Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome Organization Cyclin-dependent Protein Kinase Activity Cerebellar Neuron Development Response To Flavonoid P-type Transmembrane Transporter Activity Spindle Assembly Regulation Of Schwann Cell Differentiation Response To Hydrogen Peroxide Microtubule-based Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Protein Localization To Nucleus Response To Toxic Substance
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