MKS1 and CACNA1G

		MKS1	CACNA1G
Description		MKS transition zone complex subunit 1	calcium voltage-gated channel subunit alpha1 G
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Membrane Ciliary Transition Zone MKS Complex Ciliary Basal Body Cell Projection	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Synapse
	Molecular Function	Protein Binding	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity High Voltage-gated Calcium Channel Activity Low Voltage-gated Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Scaffold Protein Binding
	Biological Process	Neural Tube Closure Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Left/right Symmetry Regulation Of Smoothened Signaling Pathway Epithelial Structure Maintenance Cell Projection Organization Embryonic Digit Morphogenesis Motile Cilium Assembly Embryonic Skeletal System Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Head Development Cardiac Septum Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Common Bile Duct Development Non-motile Cilium Assembly Embryonic Brain Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Action Potential Regulation Of Heart Rate Sinoatrial Node Development Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Response To Nickel Cation Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Biological Quality Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction SA Node Cell Action Potential AV Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Signaling AV Node Cell To Bundle Of His Cell Signaling Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane
Pathways		Hedgehog 'off' state Anchoring of the basal body to the plasma membrane	NCAM1 interactions Smooth Muscle Contraction
Drugs			Ergocalciferol Enflurane Trimethadione Spironolactone Cinnarizine Ethosuximide Nicardipine Nicardipine Verapamil Verapamil Zonisamide Nifedipine Mibefradil Flunarizine Methsuximide Nilvadipine Cannabidiol Trimebutine Barnidipine Benidipine Efonidipine Efonidipine Efonidipine Manidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases		Meckel syndrome (MKS); Meckel-Gruber syndrome Bardet-Biedl syndrome (BBS)
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Adventurousness ( 30643258) Alzheimer's disease (cognitive decline) ( 23535033) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 32439900) Total cholesterol levels ( 30498476)
Interacting Genes		3 interacting genes: DDX24 RNF34 TMEM67	2 interacting genes: RANBP9 UBQLN4
Entrez ID		54903	8913
HPRD ID		07900	04961
Ensembl ID		ENSG00000011143	ENSG00000006283
Uniprot IDs		A0A7I2V2M0 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0	O43497
PDB IDs			6KZO 6KZP
Enriched GO Terms of Interacting Partners?		Icosanoid Transmembrane Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport AV Node Cell To Bundle Of His Cell Signaling Response To Nickel Cation Low Voltage-gated Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Signaling Macromolecule Catabolic Process Wnt Receptor Catabolic Process Regulation Of Oxygen Metabolic Process Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential ABC-type Bile Acid Transporter Activity SA Node Cell To Atrial Cardiac Muscle Cell Communication AV Node Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential SA Node Cell Action Potential	Common Bile Duct Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytosolic Proteasome Complex K48-linked Polyubiquitin Modification-dependent Protein Binding
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