BSPRY and SLC34A1

Number of citations: 0 (PubMedID 11099500)
Data Source: HPRD (two hybrid)

		BSPRY	SLC34A1
Name		B-box and SPRY domain containing	solute carrier family 34 member 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Nucleoplasm Endosome Cytosol Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Nuclear Speck Brush Border Membrane Vesicle Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Sodium:phosphate Symporter Activity Protein Binding Symporter Activity PDZ Domain Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Innate Immune Response Cellular Response To Leukemia Inhibitory Factor	Ossification Kidney Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Response To Nutrient Glycoprotein Metabolic Process Response To Xenobiotic Stimulus Response To Lead Ion Cellular Response To Phosphate Starvation Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion Response To Estradiol Response To Vitamin A Phosphate Ion Transmembrane Transport Response To Potassium Ion Indole Metabolic Process Response To Peptide Hormone Sodium-dependent Phosphate Transport Positive Regulation Of Membrane Potential Response To Cadmium Ion Response To Mercury Ion Phosphate Ion Homeostasis Response To Growth Hormone Response To Parathyroid Hormone Cellular Response To Metal Ion Cellular Response To Parathyroid Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Staurosporine Response To Thyroid Hormone Dentinogenesis Sodium Ion Import Across Plasma Membrane Gentamycin Metabolic Process Response To Peptide Arsenate Ion Transmembrane Transport Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport
Pathways		None	Type II Na+/Pi cotransporters Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) Surfactant metabolism
Diseases		None	Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Lead levels in blood ( 25820613 ) Neutrophil percentage of white cells ( 32888494 )	Activated partial thromboplastin time ( 22703881 ) Asthma ( 32296059 ) Calcium levels ( 24068962 ) Chronic kidney disease ( 31152163 20383146 26831199 ) Creatinine levels ( 28270201 31015462 29403010 ) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Hematocrit ( 29403010 ) Inflammatory bowel disease ( 28067908 ) Kidney stones ( 31729369 26272126 ) Nephrolithiasis ( 22396660 ) Phosphorus levels ( 29403010 ) Red blood cell count ( 29403010 ) Serum parathyroid hormone levels ( 27927781 ) Ulcerative colitis ( 28067908 ) Urinary electrolytes (magnesium/calcium ratio) ( 27915449 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Novel Interactors		1 novel interactors: FKBP15	None recorded
Interacting Genes		3 interacting genes: SLC34A1 YWHAZ ZYX	11 interacting genes: BSPRY FHL2 HPCAL1 HSP90AA1 HSP90AB1 MAST2 NHERF1 NHERF2 PDZK1 PEX19 YIF1A
Entrez ID		54836	6569
HPRD ID		16566	08918
Ensembl ID		ENSG00000119411	ENSG00000131183
Uniprot IDs		Q5W0U4	Q06495 Q7Z725 Q86VN6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Phosphate Transmembrane Transport Arsenate Ion Transmembrane Transport Indole Metabolic Process Gentamycin Metabolic Process Cellular Response To Phosphate Starvation Cellular Response To Starvation Vesicle Positive Regulation Of Sodium-dependent Phosphate Transport Synaptic Target Recognition Cellular Response To Staurosporine Response To Starvation Regulation Of Sodium-dependent Phosphate Transport Golgi Reassembly Dentinogenesis Cellular Response To Nutrient Levels Phosphoserine Residue Binding Actin Cytoskeleton Sodium-dependent Phosphate Transport Regulation Of Phosphate Transport Intracellular Phosphate Ion Homeostasis Response To Mercury Ion Establishment Of Golgi Localization Positive Regulation Of Membrane Potential Cellular Response To Parathyroid Hormone Stimulus Sodium:phosphate Symporter Activity Phosphate Ion Transmembrane Transport Response To Vitamin A Response To Growth Hormone Response To Parathyroid Hormone Regulation Of Lysosome Organization Golgi Localization Focal Adhesion Response To Magnesium Ion Phosphate Ion Transport Antibacterial Innate Immune Response Tricarboxylic Acid Metabolic Process Response To Lead Ion Phosphate Ion Homeostasis Response To Nutrient Levels Response To Potassium Ion Response To Thyroid Hormone Stress Fiber Assembly Contractile Actin Filament Bundle Assembly Sodium Ion Import Across Plasma Membrane Response To Peptide Regulation Of Synapse Maturation Respiratory System Process Import Into Cell Peptidyl-prolyl Cis-trans Isomerase Activity	Brush Border Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Phosphatase Binding Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Protein Localization To Membrane Apical Plasma Membrane Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Microvillus Membrane Cellular Localization Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Protein Localization To Plasma Membrane ATP-dependent Protein Folding Chaperone Protein Folding Positive Regulation Of Nitric Oxide Biosynthetic Process Localization Within Membrane Positive Regulation Of Nitric Oxide Metabolic Process Intracellular Protein Localization Tau Protein Binding Protein Localization To Cell Periphery Protein Stabilization Cellular Response To Heat CTP Binding DATP Binding Protein Folding Chaperone Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Renal Phosphate Ion Absorption Regulation Of Nitric Oxide Biosynthetic Process Membrane Regulation Of Nitric Oxide Metabolic Process Atrial Cardiac Muscle Cell Development Regulation Of Cell Size Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex PDZ Domain Binding Peroxisome Membrane Targeting Sequence Binding