TMEM106B and PHF14

		TMEM106B	PHF14
Description		transmembrane protein 106B	PHD finger protein 14
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Late Endosome Membrane	Chromatin Nucleus Chromosome Cytoplasm
	Molecular Function	Protein Binding ATPase Binding	Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Histone Reader Activity
	Biological Process	Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Lysosome Localization Dendrite Morphogenesis Neuron Cellular Homeostasis Positive Regulation Of Dendrite Development Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization	Negative Regulation Of Transcription By RNA Polymerase II Germinal Center B Cell Differentiation Chromatin Organization Negative Regulation Of Cell Population Proliferation Mesenchymal Cell Proliferation Lung Alveolus Development Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Alzheimer's disease (APOE e4 interaction) ( 25778476) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cigarettes smoked per day in Schizophrenia ( 33691233) Coronary artery disease ( 33020668 29212778) Crohn's disease ( 32581322) Depression ( 33859377 29700475) Differential aging (frontal cortex) ( 28330615) Differential aging in older adults (frontal cortex) ( 28330615) Experiencing mood swings ( 29500382) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) General factor of neuroticism ( 30867560) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Idiopathic dilated cardiomyopathy ( 29495422) Lifetime anxiety disorder ( 31748690) Liver enzyme levels (alkaline phosphatase) ( 33972514) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Neuroticism ( 29255261) Plasma kynurenine levels in major depressive disorder ( 29317604) Residual cognition ( 28441426) Response to amphetamines ( 22952603) Response to taxane treatment (paclitaxel) ( 23006423) Serum alkaline phosphatase levels ( 33547301) Tourette syndrome ( 22889924) Triglycerides ( 30275531)	Metabolite levels ( 23823483) Self-reported childhood asthma in adult smokers ( 30373671)
Interacting Genes		1 interacting genes: TMEM106C	1 interacting genes: PCBD2
Entrez ID		54664	9678
HPRD ID		07745	17845
Ensembl ID		ENSG00000106460	ENSG00000106443
Uniprot IDs		Q9NUM4	B4DG57 O94880
PDB IDs		7QVC 7QVF 7QWG 7QWL 7QWM 7SAQ 7SAR 7SAS 7TMC 7U10 7U11 7U12 7U13 7U14 7U15 7U16 7U17 7U18 7X83 7X84 8B7D 8F9K 8J7N 8J7P 8OTD 8OTE 8X5H 9FNB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Mesenchymal Cell Proliferation Germinal Center B Cell Differentiation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Histone Reader Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Mature B Cell Differentiation Involved In Immune Response Mature B Cell Differentiation Regulation Of Mesenchymal Cell Proliferation Lung Alveolus Development B Cell Activation Involved In Immune Response	Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization Protein Catabolic Process In The Vacuole Positive Regulation Of Dendrite Development 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tetrahydrobiopterin Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process Lysosomal Lumen Acidification Regulation Of Lysosomal Lumen PH Diol Metabolic Process Pteridine-containing Compound Metabolic Process Vacuolar Acidification Lysosome Organization Dendrite Morphogenesis Lysosome Localization Intracellular PH Reduction Regulation Of Vacuole Organization Neuron Cellular Homeostasis ATPase Binding Regulation Of Cellular PH Regulation Of Intracellular PH Regulation Of PH Regulation Of Dendrite Development
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