TMEM106B

Description		transmembrane protein 106B
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Late Endosome Membrane
	Molecular Function	Protein Binding ATPase Binding
	Biological Process	Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Lysosome Localization Dendrite Morphogenesis Neuron Cellular Homeostasis Positive Regulation Of Dendrite Development Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Alzheimer's disease (APOE e4 interaction) ( 25778476) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cigarettes smoked per day in Schizophrenia ( 33691233) Coronary artery disease ( 33020668 29212778) Crohn's disease ( 32581322) Depression ( 33859377 29700475) Differential aging (frontal cortex) ( 28330615) Differential aging in older adults (frontal cortex) ( 28330615) Experiencing mood swings ( 29500382) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) General factor of neuroticism ( 30867560) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Idiopathic dilated cardiomyopathy ( 29495422) Lifetime anxiety disorder ( 31748690) Liver enzyme levels (alkaline phosphatase) ( 33972514) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Neuroticism ( 29255261) Plasma kynurenine levels in major depressive disorder ( 29317604) Residual cognition ( 28441426) Response to amphetamines ( 22952603) Response to taxane treatment (paclitaxel) ( 23006423) Serum alkaline phosphatase levels ( 33547301) Tourette syndrome ( 22889924) Triglycerides ( 30275531)
Novel Interacting Genes		1 novel interacting genes: PHF14
Interacting Genes		1 interacting genes: TMEM106C
Entrez ID		54664
HPRD ID		07745
Ensembl ID		ENSG00000106460
Uniprot IDs		Q9NUM4
PDB IDs		7QVC 7QVF 7QWG 7QWL 7QWM 7SAQ 7SAR 7SAS 7TMC 7U10 7U11 7U12 7U13 7U14 7U15 7U16 7U17 7U18 7X83 7X84 8B7D 8F9K 8J7N 8J7P 8OTD 8OTE 8X5H 9FNB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Mesenchymal Cell Proliferation Germinal Center B Cell Differentiation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Histone Reader Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Mature B Cell Differentiation Involved In Immune Response Mature B Cell Differentiation Regulation Of Mesenchymal Cell Proliferation Lung Alveolus Development B Cell Activation Involved In Immune Response
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