PARP14 and NPHP3

		PARP14	NPHP3
Description		poly(ADP-ribose) polymerase family member 14	nephrocystin 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Extracellular Region Cytosol Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base
	Molecular Function	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding NAD+ Binding NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Gene Expression Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of Type II Interferon-mediated Signaling Pathway Protein Poly-ADP-ribosylation Positive Regulation Of Interleukin-4-mediated Signaling Pathway	Kidney Development Heart Looping Atrial Septum Development Lipid Metabolic Process Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Non-motile Cilium Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein	Trafficking of myristoylated proteins to the cilium
Drugs
Diseases			Renal-hepatic-pancreatic dysplasia Meckel syndrome (MKS); Meckel-Gruber syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 21102462 27182965) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: GPI PARP10	3 interacting genes: ATXN1 DYSF NPHP1
Entrez ID		54625	27031
HPRD ID		11421	06417
Ensembl ID		ENSG00000173193	ENSG00000113971
Uniprot IDs		Q460N5 Q8N546	Q7Z494
PDB IDs		3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W 6WE2 6WE3 6WE4 7D2C 7L9Y 7LUN 7R3L	5L7K
Enriched GO Terms of Interacting Partners?		Nicotinamide Nucleotide Metabolic Process Glucose-6-phosphate Isomerase Activity Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Monosaccharide Binding Maintenance Of Animal Organ Identity Ureter Development Ciliary Inversin Compartment Determination Of Digestive Tract Left/right Asymmetry Determination Of Pancreatic Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Negative Regulation Of Protein K63-linked Ubiquitination NAD+-protein-lysine ADP-ribosyltransferase Activity Fructose 6-phosphate Metabolic Process Carbohydrate Derivative Binding Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Erythrocyte Homeostasis Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Convergent Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Atrial Septum Development Kidney Morphogenesis NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Protein Polyubiquitination Protein Auto-ADP-ribosylation NAD+ Biosynthetic Process Via The Salvage Pathway NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Protein K63-linked Ubiquitination Glycolytic Process Through Glucose-6-phosphate Response To Immobilization Stress Nucleobase-containing Small Molecule Metabolic Process Nucleoside Phosphate Metabolic Process Response To Muscle Stretch Purine-containing Compound Metabolic Process Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Glucose Catabolic Process Canonical Glycolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Protein Polyubiquitination NAD+ Biosynthetic Process Viral Protein Processing Translesion Synthesis Pyridine Nucleotide Biosynthetic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Protein Poly-ADP-ribosylation K63-linked Polyubiquitin Modification-dependent Protein Binding	Double-strand Break Repair Via Nonhomologous End Joining
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