ARL15 and TUBB2A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)

		ARL15	TUBB2A
Description		ARF like GTPase 15	tubulin beta 2A class IIa
Image
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Extracellular Exosome Mitotic Spindle Extracellular Vesicle
	Molecular Function	Nucleotide Binding Molecular_function GTPase Activity Protein Binding GTP Binding	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Biological_process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule-based Process Cerebral Cortex Development
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			CYT997 Phenethyl Isothiocyanate
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 20011104 22479202 31178129) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alanine aminotransferase levels ( 33547301) Alcohol dependence (age at onset) ( 24962325) Alcoholic chronic pancreatitis ( 28754779) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Brown vs. black hair color ( 30531825) Circulating leptin levels or type 2 diabetes ( 32341051) Coffee consumption ( 31046077) Coronary artery disease ( 29212778) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708 31015462 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting insulin ( 34059833) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glycine levels ( 30837465) HDL cholesterol ( 20686565 30275531 24097068) HDL cholesterol levels ( 28334899 32203549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung function (FVC) ( 30804560 28166213) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolite levels ( 31628463) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 23918589) Right lateral prefrontal cortical growth ( 29682794) Systolic blood pressure ( 27841878) Systolic blood pressure (dietary potassium intake interaction) ( 29212900) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 28869590 29358691 30718926 30054458 24509480 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urinary magnesium excretion ( 31993563) Urinary magnesium-to-creatinine ratio ( 29093028) Waist circumference adjusted for body mass index ( 25673412 34021172) Youthful appearance (self-reported) ( 32339537)	Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 27863252 32888494)
Interacting Genes		14 interacting genes: B4GALT3 CCDC90B CRMP1 FUNDC2 GAPDH GRIPAP1 MEOX2 PDE6D PTN RPL8 TFG TUBB2A UBR1 UNC119	28 interacting genes: ACD ARL15 ARNT CHGB DISC1 DUX4 HGS HMMR LAMA4 LINC01554 OGT PAFAH1B3 POT1 PSMD11 PTPRS RABAC1 RIC8A RPA2 RPLP1 RSPH1 SAT1 SDC3 SERPINB9 TERF1 TK1 TNIK TPT1 UPF2
Entrez ID		54622	7280
HPRD ID		12471
Ensembl ID		ENSG00000185305	ENSG00000137267
Uniprot IDs		Q9NXU5	Q13885
PDB IDs		8F6D	7NVN 8V3O 8V3P
Enriched GO Terms of Interacting Partners?			Telomeric DNA Binding Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Assembly Telomere Maintenance Negative Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric D-loop Disassembly Telomeric Loop Disassembly Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Spermidine Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Ectoderm Development Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Cell-cell Adhesion Involved In Gastrulation Glutamatergic Synapse
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