DPH5 and SLC71A1

		DPH5	SLC71A1
Description		diphthamide biosynthesis 5	solute carrier family 71 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Membrane
	Molecular Function	Methyltransferase Activity Transferase Activity Diphthine Methyl Ester Synthase Activity	Transmembrane Transporter Activity
	Biological Process	Protein Histidyl Modification To Diphthamide Methylation	Acrosome Assembly Spermatogenesis Spermatid Development Spermatid Nucleus Differentiation Sperm Mitochondrion Organization Transmembrane Transport
Pathways		Synthesis of diphthamide-EEF2
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Irritable bowel syndrome ( 29673008) QT interval (drug interaction) ( 23459443)
Interacting Genes			1 interacting genes: HTR2C
Entrez ID		51611	64645
HPRD ID		13037	11022
Ensembl ID		ENSG00000117543	ENSG00000156875
Uniprot IDs		B3KWP1 Q9H2P9	Q96MC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm Mitochondrion Organization Golgi Cis Cisterna Membrane Zinc Ion Import Into Golgi Lumen Spermatid Nucleus Differentiation Zinc Ion Import Into Organelle Monoatomic Cation Transmembrane Transporter Activity Acrosome Assembly Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Intracellular Zinc Ion Homeostasis Cytoplasmic Vesicle Sarcoplasmic Reticulum Membrane	Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding G Protein-coupled Serotonin Receptor Complex Regulation Of Corticotropin-releasing Hormone Secretion Diphthine Methyl Ester Synthase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Protein Histidyl Modification To Diphthamide Serotonin Binding Serotonin Receptor Signaling Pathway Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Appetite CGMP-mediated Signaling Behavioral Fear Response Regulation Of Phospholipid Metabolic Process Behavioral Defense Response Fear Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Fat Cell Differentiation Multicellular Organismal Response To Stress Feeding Behavior Calcium Ion Transmembrane Import Into Cytosol Regulation Of Calcium-mediated Signaling
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