DPH5 and SLC30A7

		DPH5	SLC30A7
Description		diphthamide biosynthesis 5	solute carrier family 30 member 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Cytoplasm Mitochondrion Golgi Apparatus Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Golgi Cis Cisterna Membrane
	Molecular Function	Methyltransferase Activity Transferase Activity Diphthine Methyl Ester Synthase Activity	Zinc Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Identical Protein Binding
	Biological Process	Protein Histidyl Modification To Diphthamide Methylation	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Into Golgi Lumen
Pathways		Synthesis of diphthamide-EEF2
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Irritable bowel syndrome ( 29673008) QT interval (drug interaction) ( 23459443)	Multiple sclerosis ( 21833088 31604244)
Interacting Genes
Entrez ID		51611	148867
HPRD ID		13037	15369
Ensembl ID		ENSG00000117543	ENSG00000162695
Uniprot IDs		B3KWP1 Q9H2P9	Q8NEW0
PDB IDs			8J7T 8J7U 8J7V 8J7W 8J7X 8J7Y 8J80
Enriched GO Terms of Interacting Partners?		Sperm Mitochondrion Organization Golgi Cis Cisterna Membrane Zinc Ion Import Into Golgi Lumen Spermatid Nucleus Differentiation Zinc Ion Import Into Organelle Monoatomic Cation Transmembrane Transporter Activity Acrosome Assembly Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Intracellular Zinc Ion Homeostasis Cytoplasmic Vesicle Sarcoplasmic Reticulum Membrane	Skeletal Muscle Satellite Cell Commitment Diphthine Methyl Ester Synthase Activity Skeletal Muscle Satellite Cell Differentiation Protein Histidyl Modification To Diphthamide Spinal Cord Association Neuron Differentiation Dorsal/ventral Neural Tube Patterning Positive Regulation Of Myoblast Proliferation Skeletal Muscle Tissue Regeneration Regulation Of Myoblast Proliferation Regulation Of Chromatin Organization Cell Differentiation In Spinal Cord Neuron Fate Commitment Regulation Of Cell Fate Commitment Embryonic Skeletal System Development Tissue Regeneration Skeletal Muscle Tissue Development Dorsal/ventral Pattern Formation Skeletal Muscle Cell Differentiation
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