VPS54 and MOGS

		VPS54	MOGS
Description		VPS54 subunit of GARP complex	mannosyl-oligosaccharide glucosidase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	GARP Complex Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Syntaxin Binding	Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	In Utero Embryonic Development Apoptotic DNA Fragmentation Protein Targeting To Lysosome Protein Targeting To Vacuole Intracellular Calcium Ion Homeostasis Golgi To Vacuole Transport Striated Muscle Contraction Mitochondrion Organization Vacuole Organization Lysosomal Transport Neuromuscular Synaptic Transmission Skeletal Muscle Tissue Development Intracellular Protein Localization Gene Expression Ubiquitin Recycling Microglia Differentiation Protein Transport Respiratory Electron Transport Chain Sphingolipid Catabolic Process Protein Localization To Cell Surface Limb Morphogenesis Post-embryonic Forelimb Morphogenesis Synaptic Transmission, Glutamatergic Regulation Of Growth Retrograde Transport, Endosome To Golgi Protein Targeting To ER Response To Antibiotic Spermatid Differentiation Skeletal Muscle Tissue Growth Astrocyte Differentiation Neuron Projection Morphogenesis Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuron Apoptotic Process Response To Calcium Ion Synaptic Transmission, GABAergic L-glutamate Import Neurofilament Cytoskeleton Organization Limb Development Motor Behavior Thrombin-activated Receptor Signaling Pathway Cellular Response To Progesterone Stimulus Vesicle-mediated Cholesterol Transport Motor Neuron Apoptotic Process Neural Tissue Regeneration Neuroinflammatory Response Negative Regulation Of Motor Neuron Apoptotic Process	Carbohydrate Metabolic Process Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process Viral Protein Processing
Pathways		Retrograde transport at the Trans-Golgi-Network	Defective MOGS causes CDG-2b N-glycan trimming in the ER and Calnexin/Calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diastolic blood pressure ( 30224653)
Interacting Genes		5 interacting genes: DSCAM DSCR9 DYRK1A KLHL20 VPS51	1 interacting genes: CHGB
Entrez ID		51542	7841
HPRD ID		10302	03214
Ensembl ID		ENSG00000143952	ENSG00000115275
Uniprot IDs		Q9P1Q0	A0A384MDR6 Q13724 Q58F09
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Dendrite Histone H3T45 Kinase Activity Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Type II Interferon Binding Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Protein K33-linked Ubiquitination Cytosolic Transport GARP Complex Trans-Golgi Network EARP Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding
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