GMPR

Description		guanosine monophosphate reductase
Image
GO Annotations	Cellular Component	Cytosol GMP Reductase Complex
	Molecular Function	Catalytic Activity GMP Reductase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Purine Nucleobase Metabolic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Response To Cold
Pathways		Purine salvage Regulation of MITF-M dependent genes involved in invasion
Drugs		Guanosine-5'-Monophosphate
Diseases
GWAS		Gambling ( 22780124) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29874175 24952745) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Response to statins (LDL cholesterol change) ( 22331829) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Novel Interacting Genes		3 novel interacting genes: CD83 FAM8A1 RIPK1
Interacting Genes
Entrez ID		2766
HPRD ID		00754
Ensembl ID		ENSG00000137198
Uniprot IDs		P36959
PDB IDs		2BLE 2BWG
Enriched GO Terms of Interacting Partners?		Ripoptosome Positive Regulation Of MiRNA Processing Death-inducing Signaling Complex Positive Regulation Of Interleukin-6-mediated Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Leukocyte Differentiation Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Necroptotic Process Negative Regulation Of Interleukin-4 Production Hrd1p Ubiquitin Ligase Complex Positive Regulation Of Cell Development JUN Kinase Kinase Kinase Activity Necroptotic Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Hemopoiesis Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Cytokine Production Positive Regulation Of Macrophage Differentiation Regulation Of MiRNA Processing Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Necroptotic Process Regulation Of Regulatory NcRNA Processing Death Receptor Binding Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Protein Catabolic Process Negative Regulation Of Programmed Necrotic Cell Death Amyloid Fibril Formation Regulation Of Macrophage Differentiation T Cell Apoptotic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Regulation Of Necroptotic Process Regulation Of Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Lymphocyte Apoptotic Process Response To Stress Regulation Of Programmed Necrotic Cell Death Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-2 Production Regulation Of Cell Development Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Cell Differentiation Positive Regulation Of Interleukin-10 Production Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Leukocyte Apoptotic Process
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