SEPSECS and DNAH1

		SEPSECS	DNAH1
Description		Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	dynein axonemal heavy chain 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Inner Dynein Arm Cell Projection
	Molecular Function	TRNA Binding RNA Binding Protein Binding Transferase Activity O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Selenocysteine Incorporation Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec Translation	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Sperm Axoneme Assembly Flagellated Sperm Motility Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility
Pathways		Selenocysteine synthesis
Drugs		Pyridoxal phosphate
Diseases
GWAS		Tonsillectomy ( 27182965 28928442)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Chronotype ( 30696823) Electroencephalogram traits ( 25387704) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: DTX2
Entrez ID		51091	25981
HPRD ID		11561	11790
Ensembl ID		ENSG00000109618	ENSG00000114841
Uniprot IDs		A0A7P0TA23 A1A4F3 Q9HD40	A0A140VJI6 Q9P2D7
PDB IDs		3HL2 4ZDL 4ZDO 4ZDP 7L1T 7MDL 8G9Z	8I3J 8J07
Enriched GO Terms of Interacting Partners?		Inner Dynein Arm Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Sperm Axoneme Assembly Dynein Complex Protein K11-linked Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Post-translational Protein Modification Protein Branched Polyubiquitination Protein Ubiquitination Nuclear Periphery Protein Modification By Small Protein Conjugation Anaphase-promoting Complex Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Axoneme Assembly	DNA/RNA Helicase Activity RNA Binding TRNA Processing Growth Plate Cartilage Chondrocyte Development Positive Regulation Of Centrosome Duplication Chondrocyte Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Protein Localization To Chromosome, Telomeric Region O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec MPP7-DLG1-LIN7 Complex
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