MRPS7 and ASXL1

		MRPS7	ASXL1
Description		mitochondrial ribosomal protein S7	ASXL transcriptional regulator 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Nucleus Nucleoplasm PR-DUB Complex
	Molecular Function	RNA Binding MRNA Binding Structural Constituent Of Ribosome RRNA Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Translation Mitochondrial Translation	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	UCH proteinases
Drugs
Diseases			C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: PTEN UBC	8 interacting genes: APP BAP1 BRD4 FOXK1 GOLGA6L9 SRPK1 STAT3 UBC
Entrez ID		51081	171023
HPRD ID		17601	16516
Ensembl ID		ENSG00000125445	ENSG00000171456
Uniprot IDs		Q9Y2R9	A0A2R8Y5U1 Q498B9 Q8IXJ9
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2	8H1T 8SVF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Vesicle Clustering Protein Dephosphorylation Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphoprotein Phosphatase Activity Dephosphorylation Negative Regulation Of Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Protein Tyrosine Phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Developmental Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Insulin Receptor Recycling PR-DUB Complex Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Positive Regulation Of Intracellular Signal Transduction Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Interleukin-6-mediated Signaling Pathway Lung Saccule Development Regulation Of Kidney Size Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cell Development Postsynaptic Density Assembly Negative Regulation Of Type II Interferon-mediated Signaling Pathway Bone Marrow Development Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Locomotor Rhythm Nucleoplasm Negative Regulation Of Locomotion Regulation Of Cell Differentiation Cellular Response To Electrical Stimulus Regulation Of Protein Phosphorylation	Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity
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