ATL1 and DNAAF2

		ATL1	DNAAF2
Description		atlastin GTPase 1	dynein axonemal assembly factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Axon Cell Projection Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane Endoplasmic Reticulum Subcompartment Golgi Cis Cisterna Membrane	Extracellular Region Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Cilium Ciliary Basal Body Protein Folding Chaperone Complex Dynein Axonemal Particle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding GTPase-dependent Fusogenic Activity	Protein Binding
	Biological Process	Endoplasmic Reticulum Organization Axonogenesis Endoplasmic Reticulum Membrane Fusion Protein Homooligomerization Endoplasmic Reticulum Tubular Network Membrane Organization	In Utero Embryonic Development Epithelial Cilium Movement Involved In Extracellular Fluid Movement Response To Retinoic Acid Outer Dynein Arm Assembly Inner Dynein Arm Assembly Protein Stabilization Establishment Of Localization In Cell Cilium-dependent Cell Motility Establishment Of Left/right Asymmetry Axonemal Dynein Complex Assembly
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Femur bone mineral density x serum urate levels interaction ( 34046847) Periodontal disease-related phenotype (Socransky) ( 24347629)	Carotid intima media thickness ( 26343869)
Interacting Genes		1 interacting genes: SYVN1	3 interacting genes: APP HMGB1 RNF10
Entrez ID		51062	55172
HPRD ID		05918	12627
Ensembl ID		ENSG00000198513	ENSG00000165506
Uniprot IDs		A0A0S2Z5A2 A0A0S2Z5B0 Q53F53 Q8WXF7	Q9NVR5
PDB IDs		3Q5D 3Q5E 3QNU 3QOF 4IDN 4IDO 4IDP 4IDQ 6B9D 6B9E 6B9F 6B9G 6XJN 7OL3
Enriched GO Terms of Interacting Partners?		Nucleoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cullin-RING Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Cul2-RING Ubiquitin Ligase Complex Microtubule Anchoring At Centrosome Collateral Sprouting Corticospinal Tract Morphogenesis Ciliary Basal Body Centriolar Subdistal Appendage Ciliary Transition Fiber Centriole-centriole Cohesion Microtubule Nucleation By Microtubule Organizing Center Microtubule Minus-end Binding Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Microtubule Anchoring At Microtubule Organizing Center Dynein Axonemal Particle Regulation Of Protein Stability Outer Dynein Arm Assembly Establishment Of Left/right Asymmetry Protein Stabilization Inner Dynein Arm Assembly Hrd1p Ubiquitin Ligase ERAD-L Complex Retrograde Protein Transport, ER To Cytosol Protein Alpha-1,2-demannosylation Negative Regulation Of T-helper 1 Type Immune Response Endoplasmic Reticulum Mannose Trimming Smooth Endoplasmic Reticulum Immature B Cell Differentiation Ubiquitin-specific Protease Binding Hrd1p Ubiquitin Ligase Complex Derlin-1 Retrotranslocation Complex Protein Deglycosylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Endoplasmic Reticulum Quality Control Compartment Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Protein Folding Chaperone Complex Protein Exit From Endoplasmic Reticulum	RAGE Receptor Binding Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Positive Regulation Of Interleukin-1 Production Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Chemoattractant Activity Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Monocyte Chemotaxis Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Endoplasmic Reticulum Subcompartment 2-hydroxyglutarate Dehydrogenase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Type II Interferon Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Receptor Ligand Activity Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Myeloid Leukocyte Activation Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Microglia Development
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