TAS2R14 and ACSL3

Data Source: HiPPIP (Novel)

		TAS2R14	ACSL3
Name		taste 2 receptor member 14	acyl-CoA synthetase long chain family member 3
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Taste Receptor Activity Bitter Taste Receptor Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Kinase Binding Protein Domain Specific Binding Medium-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Fatty Acid-CoA Ligase Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Taste	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Neuron Differentiation Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Long-chain Fatty Acid Import Into Cell Positive Regulation Of Secretion Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste	Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs
GWAS		Caffeine consumption from tea ( 33287642 )	Mild influenza (H1N1) infection ( 26379185 )
Novel Interactors		1 novel interactors: ACSL3	6 novel interactors: BARD1 CAPS MAP2 MMP13 SMARCAL1 TAS2R14
Interacting Genes		None recorded	3 interacting genes: APP NDRG1 WEE2-AS1
Entrez ID		50840	2181
HPRD ID		11989	03845
Ensembl ID		ENSG00000212127	ENSG00000123983
Uniprot IDs		Q9NYV8	O95573
PDB IDs		8RQL 8VY7 8VY9 8XQL 8XQN 8XQO 8XQP 8XQR 8XQS 8XQT 8YKY 9IIW 9IIX 9IJ9 9IJA	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Phosphatidylcholine Biosynthetic Process Medium-chain Fatty Acid-CoA Ligase Activity Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Very-low-density Lipoprotein Particle Assembly Arachidonate-CoA Ligase Activity Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Phosphatidylcholine Biosynthetic Process Long-chain Fatty Acid Import Into Cell Palmitoyl-CoA Ligase Activity Positive Regulation Of Phospholipid Biosynthetic Process Fatty Acid-CoA Ligase Activity Lipid Import Into Cell Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Phospholipid Biosynthetic Process Protein-lipid Complex Assembly Long-chain Fatty-acyl-CoA Metabolic Process Plasma Lipoprotein Particle Assembly Fatty-acyl-CoA Biosynthetic Process Regulation Of Phospholipid Metabolic Process Fatty Acid Derivative Biosynthetic Process Long-chain Fatty Acid Transport Peroxisomal Membrane Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Fatty Acid Derivative Metabolic Process Fatty Acid Transport Acyl-CoA Metabolic Process Positive Regulation Of Protein Localization To Membrane Lipid Droplet Long-chain Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Sulfur Compound Biosynthetic Process Regulation Of Protein Localization To Plasma Membrane Ligase Activity Peroxisome Monocarboxylic Acid Transport Positive Regulation Of Lipid Metabolic Process Amide Biosynthetic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Membrane Regulation Of Lipid Biosynthetic Process Mitochondrial Outer Membrane Protein Domain Specific Binding Purine-containing Compound Biosynthetic Process Sulfur Compound Metabolic Process Positive Regulation Of Protein Transport Carboxylic Acid Transport Organic Acid Transport	Main Axon Acetylcholine Receptor Activator Activity Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Lipoprotein Particle Dendrite Development Positive Regulation Of Protein Import Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Apical Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Proximal Neuron Projection Dendritic Branch Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Myeloid Leukocyte Activation Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BRCA1-B Complex Positive Regulation Of Vesicle Transport Along Microtubule Pre-mRNA 5'-splice Site Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Synaptic Vesicle Transport Basal Dendrite Nickel Cation Binding ATP-dependent DNA/DNA Annealing Activity