NDUFV1 and PDE2A

Number of citations of the paper that reports this interaction (PubMedID 33087821)
73

Data Source:
BioGRID (affinity chromatography technology)

		NDUFV1	PDE2A
Description		NADH:ubiquinone oxidoreductase core subunit V1	phosphodiesterase 2A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity FMN Binding Oxidoreductase Activity Metal Ion Binding NAD Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Nucleotide Binding Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CGMP-mediated Signaling Monocyte Differentiation Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation	cGMP effects G alpha (s) signalling events
Drugs		NADH	Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)
Interacting Genes		3 interacting genes: DRD2 EWSR1 OGT	1 interacting genes: ITSN1
Entrez ID		4723	5138
HPRD ID		01191	04041
Ensembl ID		ENSG00000167792	ENSG00000186642
Uniprot IDs		E5KNH5 P49821	O00408 Q8IW54
PDB IDs		5XTB 5XTD 5XTH 5XTI	1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission, Glutamatergic Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Xenobiotic Stimulus Regulation Of RNA Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Structural Plasticity Presynaptic Membrane Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Regulation Of Synapse Organization Cellular Response To Oxygen-containing Compound Cerebral Cortex GABAergic Interneuron Migration Circadian Regulation Of Gene Expression Regulation Of DNA-templated Transcription Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of RNA Biosynthetic Process Adenohypophysis Development Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Signal Transduction Hyaloid Vascular Plexus Regression Autophagy Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Neurotransmitter Uptake Circadian Rhythm Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Dopamine Receptor Signaling Pathway Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To CGMP 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity	Positive Regulation Of Base-excision Repair Regulation Of Base-excision Repair Regulation Of Mitotic Nuclear Division Apoptotic Process Involved In Development Regulation Of Nuclear Division Endocytosis Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Regulation Of DNA Repair Neural Crest Cell Migration Involved In Heart Formation Response To TNF Agonist Oxidized Pyrimidine DNA Binding Brexanolone Catabolic Process Stereocilium Shaft
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