NDUFV1

Description		NADH:ubiquinone oxidoreductase core subunit V1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity FMN Binding Oxidoreductase Activity Metal Ion Binding NAD Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS
Novel Interacting Genes		1 novel interacting genes: PDE2A
Interacting Genes		3 interacting genes: DRD2 EWSR1 OGT
Entrez ID		4723
HPRD ID		01191
Ensembl ID		ENSG00000167792
Uniprot IDs		E5KNH5 P49821
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission, Glutamatergic Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Xenobiotic Stimulus Regulation Of RNA Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Structural Plasticity Presynaptic Membrane Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Regulation Of Synapse Organization Cellular Response To Oxygen-containing Compound Cerebral Cortex GABAergic Interneuron Migration Circadian Regulation Of Gene Expression Regulation Of DNA-templated Transcription Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of RNA Biosynthetic Process Adenohypophysis Development Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Signal Transduction Hyaloid Vascular Plexus Regression Autophagy Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Neurotransmitter Uptake Circadian Rhythm Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Dopamine Receptor Signaling Pathway Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To CGMP 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity
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