MT-TI and TRMT10C

Number of citations of the paper that reports this interaction (PubMedID 23755257)
36

Data Source:
BioGRID (enzymatic study)

		MT-TI	TRMT10C
Description		tRNA-Ile	tRNA methyltransferase 10C, mitochondrial RNase P subunit
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid TRNA Methyltransferase Complex
	Molecular Function		TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Transferase Activity Identical Protein Binding TRNA (guanosine(9)-N1)-methyltransferase Activity TRNA (adenine(9)-N1)-methyltransferase Activity
	Biological Process		Mitochondrial RNA 5'-end Processing MRNA Processing TRNA Processing Methylation Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways			tRNA processing in the mitochondrion tRNA modification in the mitochondrion rRNA processing in the mitochondrion
Drugs
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Allergic disease (asthma, hay fever or eczema) ( 29083406) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		1 interacting genes: TRMT10C	5 interacting genes: MIR15A MIRLET7A3 MT-TI OGT WEE2-AS1
Entrez ID		4565	54931
HPRD ID			15240
Ensembl ID		ENSG00000210100	ENSG00000174173
Uniprot IDs			Q7L0Y3
PDB IDs			5NFJ 7ONU 8CBK 8CBL 8CBM 8CBO 8RR1 8RR3 8RR4 9EY0 9EY1 9EY2 9GCH
Enriched GO Terms of Interacting Partners?		TRNA (guanosine(9)-N1)-methyltransferase Activity Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing TRNA (adenine(9)-N1)-methyltransferase Activity Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Mitochondrial RNA 5'-end Processing TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing TRNA 3'-end Processing Mitochondrial TRNA Modification Mitochondrial RNA Modification Mitochondrial TRNA Processing Positive Regulation Of Mitochondrial Translation TRNA 5'-end Processing Regulation Of Mitochondrial Translation TRNA Threonylcarbamoyladenosine Metabolic Process Mitochondrial RNA Processing TRNA Methylation Mitochondrial RNA Metabolic Process Mitochondrial Nucleoid TRNA Binding RNA Methylation RNA 3'-end Processing TRNA Modification Macromolecule Methylation TRNA Processing RNA Modification Positive Regulation Of Translation Methyltransferase Activity TRNA Metabolic Process Methylation Gene Expression	Protein N-acetylglucosaminyltransferase Complex Cellular Response To Glucose Stimulus Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Response To Carbohydrate Stimulus Intracellular Glucose Homeostasis RISC Complex Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Post-transcriptional Gene Silencing Response To Monosaccharide Response To Glucose Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Response To Carbohydrate Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation Pre-mRNA 5'-splice Site Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription MRNA 5'-splice Site Recognition Regulation Of Transcription By Glucose Negative Regulation Of Gene Expression NSL Complex Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Translation U1 SnRNP Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Execution Phase Of Apoptosis
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