ART3 and ALCAM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ART3	ALCAM
Description		ADP-ribosyltransferase 3 (inactive)	activated leukocyte cell adhesion molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Exosome Side Of Membrane	Immunological Synapse Extracellular Region Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Axon Dendrite T Cell Receptor Complex Cell Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity NAD+-protein-arginine ADP-ribosyltransferase Activity	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process		Adaptive Immune Response Immune System Process Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Axon Guidance Motor Neuron Axon Guidance Retinal Ganglion Cell Axon Guidance Axon Extension Involved In Axon Guidance Neuron Projection Extension
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	L1CAM interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Hippocampal volume ( 29274321)	Adult body size ( 32376654) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Alzheimer's disease ( 33074286) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Body mass index ( 25673413) Breast cancer ( 31757997) Chronotype ( 30696823) Cortical surface area ( 32963231) Cortical surface area (visual PC2) ( 32198502) Cortical volume ( 32963231) Erectile dysfunction in type 1 diabetes ( 22704111) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 29617998) Irritable mood ( 29500382) Metabolite levels ( 23823483) Ovarian disease with few adhesions ( 28333195) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Visceral fat ( 30942860)
Interacting Genes		2 interacting genes: ALCAM PRKCD	3 interacting genes: ART3 CD6 EGFR
Entrez ID		419	214
HPRD ID		04363	03389
Ensembl ID		ENSG00000156219	ENSG00000170017
Uniprot IDs		A0A8V8TPP7 H0Y8V6 Q13508	B3KNN9 Q13740
PDB IDs			5A2F
Enriched GO Terms of Interacting Partners?		Immune Response MAML1-RBP-Jkappa- ICN1 Complex Positive Regulation Of Ephrin Receptor Signaling Pathway Club Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Pulmonary Valve Development Blood Vessel Endothelial Cell Fate Specification B Cell Activation Blood Vessel Lumenization Arterial Endothelial Cell Fate Commitment Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Myeloid Leukocyte Activation Regulation Of Cell Adhesion Involved In Heart Morphogenesis Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Phospholipid Scramblase Activity Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Endodeoxyribonuclease Activity Protein Kinase C Signaling Termination Of Signal Transduction Adaptive Immune Response Defense Response To Bacterium Endocardium Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Aortic Valve Development Hair Follicle Maturation Semi-lunar Valve Development Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Endodeoxyribonuclease Activity Regulation Of Phospholipid Catabolic Process Immune System Process Sebaceous Gland Development Dorsal Aorta Morphogenesis Endolysosome Cellular Response To Hydroperoxide Response To Bacterium Axon Extension Involved In Axon Guidance Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Timing Of Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Endothelial Tube Morphogenesis Lymphocyte Activation	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Positive Regulation Of Protein Localization To Membrane Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Arginyl-tRNA--protein Transferase Activity Cell Surface Response To Amino Acid Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Response To Butyrate Cellular Response To Hydrostatic Pressure Protein Arginylation NAD+-protein-arginine ADP-ribosyltransferase Activity Transferase Activity Extracellular Region Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Response To Lipid Lipoteichoic Acid Binding Regulation Of Protein Kinase C Signaling Transmembrane Signaling Receptor Activity Epidermal Growth Factor Binding ERBB2-EGFR Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Localization To Membrane Plasmacytoid Dendritic Cell Activation Negative Regulation Of Regulatory T Cell Differentiation MHC Class II Protein Binding Autosome Genomic Imprinting Response To Muscle Inactivity Phosphatidylinositol 3-kinase Complex, Class IB Phosphatidylinositol 3-kinase Complex 1-phosphatidylinositol-4-phosphate 3-kinase Activity Negative Regulation Of Fibroblast Apoptotic Process 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Response To Hydrostatic Pressure Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Cardiac Muscle Cell Contraction Phosphatidylinositol 3-kinase Complex, Class IA
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