MIGA1 and NEGR1

		MIGA1	NEGR1
Description		mitoguardin 1	neuronal growth regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Membrane	Extracellular Region Plasma Membrane Postsynaptic Density Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Apical Dendrite Side Of Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding
	Biological Process	Mitochondrial Fusion	Cell Adhesion Brain Development Locomotory Behavior Feeding Behavior Positive Regulation Of Neuron Projection Development Neuron Projection Development Social Behavior Cholesterol Homeostasis Fat Cell Differentiation Positive Regulation Of Saliva Secretion Neuron Projection Morphogenesis Positive Regulation Of Calcium-mediated Signaling Regulation Of Synapse Assembly Negative Regulation Of Synapse Assembly Negative Regulation Of Glial Cell Proliferation Skeletal Muscle Organ Development Cell-cell Adhesion Lipid Droplet Formation
Pathways		Synthesis of PA	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30643258) Allergic rhinitis ( 30013184) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Asthma and major depressive disorder ( 31619474) Beef consumption ( 32066663) Bipolar disorder or body mass index ( 31754094) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body composition traits ( 30026463) Body mass index ( 26961502 28892062 28448500 19079261 26426971 31888951 25673413 23563607 19079260 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Broad depression or major depressive disorder (self-reported) ( 30626913) Cervical high-risk human papilloma virus infection ( 33225922) Childhood body mass index ( 26604143 33045005) Chromium levels ( 26025379) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Diffusing capacity of carbon monoxide ( 30694715) Experiencing mood swings ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 17903294) Hip circumference ( 25673412) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Meat-related diet ( 32066663) Menarche (age at onset) ( 25231870) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity ( 23563607) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 30677029 31888951) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Rosacea symptom severity ( 29771307) Self-reported risk-taking behaviour ( 30271922) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Subcutaneous adipose tissue ( 22589738) Systemic lupus erythematosus ( 18204098) Urinary sodium excretion ( 31409800) Venlafaxine response in generalised anxiety disorder (HAMA-A score reduction after 24 weeks) ( 28437668) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		1 interacting genes: DYRK1A	2 interacting genes: LSAMP NTM
Entrez ID		374986	257194
HPRD ID		13415	14820
Ensembl ID		ENSG00000180488	ENSG00000172260
Uniprot IDs		A0A2R8YDC7 A0A2R8YF99 A0A2R8YGK2 A0AA34QW11 B4DK63 B7ZLZ8 F8W7S1 Q8NAN2	Q7Z3B1
PDB IDs			6DLD 6U6T
Enriched GO Terms of Interacting Partners?		RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Negative Regulation Of Cellular Component Organization Negative Regulation Of Microtubule Polymerization Dendrite Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation Histone H3T45 Kinase Activity Apical Dendrite Lipid Droplet Formation Positive Regulation Of Saliva Secretion Negative Regulation Of Synapse Organization Positive Regulation Of Digestive System Process Negative Regulation Of Synapse Assembly Regulation Of Saliva Secretion Negative Regulation Of Glial Cell Proliferation Tau-protein Kinase Activity Regulation Of Inclusion Body Assembly Skeletal Muscle Organ Development Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Amyloid-beta Formation Negative Regulation Of Microtubule Polymerization Or Depolymerization Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Signal Transduction By P53 Class Mediator Tau Protein Binding Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Dendritic Shaft Lipid Droplet Organization Regulation Of Amyloid Precursor Protein Catabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling Social Behavior Double-strand Break Repair Via Nonhomologous End Joining Tubulin Binding Regulation Of Microtubule Polymerization Cytoskeletal Protein Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Amide Metabolic Process Feeding Behavior Actin Filament Sterol Homeostasis	Side Of Membrane Choline Transmembrane Transporter Activity Choline Transport
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