IDI1 and LARP4B

		IDI1	LARP4B
Description		isopentenyl-diphosphate delta isomerase 1	La ribonucleoprotein 4B
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol	Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane
	Molecular Function	Magnesium Ion Binding Isopentenyl-diphosphate Delta-isomerase Activity Protein Binding Isomerase Activity Intramolecular Oxidoreductase Activity Manganese Ion Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process Sterol Biosynthetic Process Response To Stilbenoid Dimethylallyl Diphosphate Biosynthetic Process	Regulation Of Translation Positive Regulation Of Translation Positive Regulation Of 3'-UTR-mediated MRNA Stabilization
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Dimethylallyl Diphosphate
Diseases
GWAS			Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Femur bone mineral density x serum urate levels interaction ( 34046847) Neutrophil percentage of granulocytes ( 27863252) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Prostate cancer (early onset) ( 29892016) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		5 interacting genes: BARD1 BCL2L13 TXNIP WT1 ZNF655	7 interacting genes: ATXN1L C1QTNF9 DMRTB1 MAGED1 OGT PABPC1 RBPMS
Entrez ID		3422	23185
HPRD ID		07235	13787
Ensembl ID		ENSG00000067064	ENSG00000107929
Uniprot IDs		A0A8Q3WKR8 Q13907	Q92615
PDB IDs		2DHO 2I6K 2ICJ 2ICK	3PTH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death BRCA1-B Complex Regulation Of Programmed Cell Death Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Hemi-methylated DNA-binding Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Metanephric S-shaped Body Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Cellular Response To Tumor Cell BRCA1-A Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Negative Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin-modified Histone Reader Activity Negative Regulation Of Mitotic Cell Cycle Diaphragm Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Female Gonad Development Thorax And Anterior Abdomen Determination Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Double-stranded Methylated DNA Binding Metanephric Mesenchyme Development Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Cell Cycle Phase Transition Regulation Of MRNA 3'-end Processing Zinc Ion Binding Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Process Nucleolus Nephron Tubule Morphogenesis Podocyte Differentiation Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process DNA Strand Resection Involved In Replication Fork Processing Metanephric Epithelium Development	Dimethylallyl Diphosphate Biosynthetic Process Isopentenyl-diphosphate Delta-isomerase Activity Intramolecular Oxidoreductase Activity Isopentenyl Diphosphate Biosynthetic Process Isopentenyl Diphosphate Metabolic Process Isoprenoid Biosynthetic Process Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly
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