IDE and BRDT

		IDE	BRDT
Description		insulin degrading enzyme	bromodomain testis associated
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Virus Receptor Activity Catalytic Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Peptide Hormone Binding Beta-endorphin Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Protein Serine/threonine Kinase Activity Protein-macromolecule Adaptor Activity Histone Binding Histone H4 Reader Activity
	Biological Process	Proteolysis Insulin Receptor Signaling Pathway Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Symbiont Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Sperm DNA Condensation Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle
Pathways		Ub-specific processing proteases Insulin receptor recycling Peroxisomal protein import Peroxisomal protein import
Drugs		Bacitracin
Diseases
GWAS		Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 27680694 31043758) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 20581827 22885922 24509480 26818947 29358691 30297969 30718926 32499647) Waist-to-hip ratio adjusted for BMI ( 28552196)	Gestational age at birth (maternal effect) ( 28877031) Height ( 28552196) Mean corpuscular hemoglobin concentration ( 32888494)
Interacting Genes		9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5	3 interacting genes: E2F6 H4C14 VAV2
Entrez ID		3416	676
HPRD ID		00894	03684
Ensembl ID		ENSG00000119912	ENSG00000137948
Uniprot IDs		A0A3B3ISG5 A0A7I2V2P6 A0A7I2V373 B3KSB8 P14735	Q58F21
PDB IDs		2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3 7K1D 7K1E 7K1F 7RZE 7RZF 7RZG 7RZH 7RZI	2RFJ 4FLP 4KCX 5VBQ 5VBR 7BJY 7L73 7L99 7L9A 7LEJ 7LEK 7LEL 7LEM 7MRC 7MRD 7MRG 7MRH 7UBO 7UUU 8CZA 8YHS
Enriched GO Terms of Interacting Partners?		Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Regulation Of Glucose Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Growth Regulation Of Developmental Growth Receptor Ligand Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Small Molecule Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Glycolytic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Cellular Response To Oxygen-containing Compound Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Exocrine Pancreas Development Positive Regulation Of Growth Insulin Receptor Signaling Pathway Regulation Of Purine Nucleotide Metabolic Process Estrogen Response Element Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cell Cycle Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process
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