LHFPL1 and IGFBP5

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LHFPL1	IGFBP5
Name		LHFPL tetraspan subfamily member 1	insulin like growth factor binding protein 5
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Protein Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Receptor Ligand Activity
	Biological Process	None	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Cell Population Proliferation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Regulation Of Growth Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Insulin-like Growth Factor Receptor Signaling Pathway Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		None	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 ) Breast cancer ( 29059683 ) Creatinine levels ( 29403010 ) Estimated glomerular filtration rate ( 30604766 ) FEV1 ( 30804560 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Height ( 31562340 ) Hypothyroidism ( 27182965 ) Lung function (FEV1/FVC) ( 30804560 ) Metabolite levels ( 23823483 ) Mitral valve prolapse ( 26301497 ) Pulse pressure ( 27841878 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Visceral fat ( 22589738 )
Interacting Genes		5 interacting genes: IGFBP5 LAT PLP2 SEC22B THSD7A	100 interacting genes: ABHD4 ADAM12 AHNAK2 AMIGO1 ANKS6 APH1A AQP2 AQP6 AQP9 ARL13B ASGR1 BAG6 BIK BSND CD53 CERS4 CHODL CLDN2 CLDN20 CLDN6 CLDN7 CLDN9 CLEC17A CPLX4 CREB3 CXCR1 ELOVL5 ERGIC3 F2 FAM209A FCRL3 FFAR2 FHL1 FHL2 FKBP7 FN1 FNDC9 GJA5 GJA8 GJB3 GJB5 GOLM1 GPR151 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HSD17B13 IGF1 IGF2 IGFALS KCNK5 KIAA2013 KPNB1 LAPTM4B LAYN LDLRAD1 LHFPL1 LMNA LTBP1 MFF MRPS18B MS4A3 MS4A7 NCAPH2 PAPPA2 PDZK1IP1 PNO1 PROKR2 RASSF1 RHCG SAR1A SERPINE1 SLC10A6 SLC13A4 SLC35H1 SLC38A1 SLC41A2 SLC41A3 SLC61A1 SPAG4 SPP1 SYNE4 TF THAP4 THBS1 TIMMDC1 TLCD4 TMEM106A TMEM106C TMEM179B TMEM237 TMEM45A TMEM52B TMPRSS2 TMX2 TSPAN12 TSPO2 VTN
Entrez ID		340596	3488
HPRD ID		06610	00901
Ensembl ID		ENSG00000182508	ENSG00000115461
Uniprot IDs		Q86WI0	P24593
PDB IDs		Not available	1BOE 1H59 7UFG
GO Terms Enriched among Interactors		Negative Regulation Of Skeletal Muscle Hypertrophy	Membrane Plasma Membrane Protein Binding Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Connexin Complex Gap Junction Channel Activity Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Blood Coagulation Gap Junction Tight Junction Organization Positive Regulation Of Coagulation Platelet Alpha Granule Lumen Endoplasmic Reticulum Lumen Water Channel Activity Transmembrane Transport Structural Molecule Activity Cell-cell Junction Assembly Anchoring Junction Insulin-like Growth Factor Ternary Complex Peptidase Inhibitor Complex Integrin Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Water Transport One-carbon Compound Transport Positive Regulation Of Wound Healing