TAFA2 and KIR2DL5A

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		TAFA2	KIR2DL5A
Description		TAFA chemokine like family member 2	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Receptor Ligand Activity
	Biological Process	Signal Transduction Memory Visual Learning	Immune Response-regulating Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)
Interacting Genes		5 interacting genes: KIR2DL5A KIR3DL1 KIR3DL2 KIR3DL3 RNF167	3 interacting genes: PTPN11 PTPN6 TAFA2
Entrez ID		338811	57292
HPRD ID		16876	05603
Ensembl ID		ENSG00000198673
Uniprot IDs		Q8N3H0	A0A191URI1 Q8N109
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process HLA-B Specific Inhibitory MHC Class I Receptor Activity Plasma Membrane MHC Class Ib Protein Binding Cellular Response To Leucine Starvation Protein K29-linked Ubiquitination	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Type I Interferon-mediated Signaling Pathway Phosphotyrosine Residue Binding T Cell Costimulation Regulation Of Cell Adhesion Mediated By Integrin Myeloid Cell Development Negative Regulation Of T Cell Proliferation Protein Dephosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Leukocyte Proliferation Dephosphorylation Myeloid Leukocyte Activation Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Phosphoprotein Phosphatase Activity Negative Regulation Of T Cell Activation Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Negative Regulation Of Lymphocyte Activation Regulation Of Tumor Necrosis Factor Production Hemopoiesis Regulation Of Cytokine-mediated Signaling Pathway Regulation Of T Cell Proliferation Intestinal Epithelial Cell Migration Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Activation Cerebellar Cortex Formation Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of T Cell Activation Negative Regulation Of Mast Cell Activation Involved In Immune Response Negative Regulation Of Glucocorticoid Secretion Regulation Of Leukocyte Proliferation Regulation Of ERK1 And ERK2 Cascade CD27 Signaling Pathway
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