RAX and ALPK2

		RAX	ALPK2
Description		retina and anterior neural fold homeobox	alpha kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Brain Development Visual Perception Hypothalamus Development Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Limb Development	Heart Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Regulation Of Gene Expression Establishment Of Cell Polarity Regulation Of Apoptotic Process Cardiac Muscle Cell Development Epicardium Morphogenesis
Pathways
Drugs
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Alanine aminotransferase levels ( 33547301) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Hip circumference ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and systolic blood pressure (pleiotropy) ( 26920376) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549 32154731)
Interacting Genes		1 interacting genes: PAX6
Entrez ID		30062	115701
HPRD ID		03530	11019
Ensembl ID		ENSG00000134438	ENSG00000198796
Uniprot IDs		Q9Y2V3	Q86TB3
PDB IDs
Enriched GO Terms of Interacting Partners?		Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Forebrain Neuron Fate Commitment Habenula Development Oligodendrocyte Cell Fate Specification Ventral Spinal Cord Development Animal Organ Morphogenesis Pallium Development Formation Of Anatomical Boundary Iris Morphogenesis Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Epicardium Morphogenesis Type B Pancreatic Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis HMG Box Domain Binding Co-SMAD Binding Regulation Of Timing Of Cell Differentiation Negative Regulation Of Neuroblast Proliferation Dorsal/ventral Axis Specification Regulation Of Development, Heterochronic Embryonic Camera-type Eye Morphogenesis Enteroendocrine Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cell Development Negative Regulation Of Developmental Process Negative Regulation Of Neural Precursor Cell Proliferation Histone Acetyltransferase Binding Embryonic Eye Morphogenesis R-SMAD Binding Positive Regulation Of Neuroblast Proliferation Gland Morphogenesis Pituitary Gland Development Astrocyte Differentiation Photoreceptor Cell Development Establishment Of Spindle Orientation Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Signal Transduction Involved In Regulation Of Gene Expression Eye Photoreceptor Cell Development Transcription Coregulator Binding Neuron Fate Commitment Establishment Of Mitotic Spindle Localization
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