ASTE1 and NPHP3

		ASTE1	NPHP3
Description		asteroid structure-specific endonuclease 1	nephrocystin 3
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Cytosol Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Nuclease Activity DNA Endonuclease Activity Protein Binding Hydrolase Activity 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination	Kidney Development Heart Looping Atrial Septum Development Lipid Metabolic Process Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Non-motile Cilium Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways			Trafficking of myristoylated proteins to the cilium
Drugs
Diseases			Renal-hepatic-pancreatic dysplasia Meckel syndrome (MKS); Meckel-Gruber syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Phenylephrine infusion rate during anesthesia ( 31455332) Restless legs syndrome ( 29029846)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 21102462 27182965) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: XRCC4	3 interacting genes: ATXN1 DYSF NPHP1
Entrez ID		28990	27031
HPRD ID		11038	06417
Ensembl ID		ENSG00000034533	ENSG00000113971
Uniprot IDs		D6RG30 Q2TB18	Q7Z494
PDB IDs			5L7K
Enriched GO Terms of Interacting Partners?		FHA Domain Binding Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Phospholipid Translocation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Ligase Activity DNA Ligase IV Complex Maintenance Of Animal Organ Identity Ureter Development Ciliary Inversin Compartment Determination Of Digestive Tract Left/right Asymmetry Determination Of Pancreatic Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Atrial Septum Development Positive Regulation Of Phospholipid Transport Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Convergent Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Kidney Morphogenesis Cellular Response To Lithium Ion Regulation Of Plasma Membrane Organization Response To Lithium Ion V(D)J Recombination Regulation Of Non-canonical Wnt Signaling Pathway Protein Localization To Site Of Double-strand Break Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Photoreceptor Cell Maintenance Regulation Of Membrane Lipid Distribution Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cardiac Septum Development Extracellular Transport Ciliary Base Non-motile Cilium Assembly Double-strand Break Repair Via Nonhomologous End Joining Heart Looping Embryonic Heart Tube Morphogenesis Positive Regulation Of Lipid Transport Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Site Of Double-strand Break Lung Development	Double-strand Break Repair Via Nonhomologous End Joining
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