SEC14L4 and HAO2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC14L4	HAO2
Description		SEC14 like lipid binding 4	hydroxyacid oxidase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Protein Binding Lipid Binding	(S)-2-hydroxy-acid Oxidase Activity Protein Binding FMN Binding Oxidoreductase Activity
	Biological Process		Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Oxidation
Pathways			Peroxisomal lipid metabolism Peroxisomal protein import Peroxisomal protein import
Drugs		Vitamin E	Flavin mononucleotide
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) hemolysis of donated blood (oxidative) ( 34014839) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Monobrow ( 27182965) Ovarian cancer ( 30557369) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Urate levels ( 31578528)
Interacting Genes		21 interacting genes: BMF CRX CTAG1A CTAG1B HAO2 INCA1 KRT31 KRT34 MEOX1 MEOX2 PAX5 PAX6 PLEKHF2 REL RHOU SERTAD1 TCF4 TEPSIN TRIM54 USHBP1 ZMYND12	2 interacting genes: PEX5 SEC14L4
Entrez ID		284904	51179
HPRD ID		15312	05532
Ensembl ID		ENSG00000133488	ENSG00000116882
Uniprot IDs		B2RMR2 B3KRP9 Q9UDX3	Q9NYQ3
PDB IDs		4TLG
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Somite Specification Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding HMG Box Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Segment Specification Somite Development TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Metabolic Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Coated Vesicle Membrane	Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Cerebral Cortex Neuron Differentiation Receptor Recycling Peroxisome Organization Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth Very Long-chain Fatty Acid Metabolic Process Forebrain Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane Regulation Of Multicellular Organism Growth Protein Transmembrane Transport Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Protein Tetramerization Cellular Response To Reactive Oxygen Species Neuromuscular Process Mitochondrial Membrane Organization
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