KCNMB4 and CSDE1

		KCNMB4	CSDE1
Description		potassium calcium-activated channel subfamily M regulatory beta subunit 4	cold shock domain containing E1
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Synapse	P-body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex MCRD-mediated MRNA Stability Complex
	Molecular Function	Protein Binding Calcium-activated Potassium Channel Activity Potassium Channel Regulator Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Stem-loop Binding LncRNA Binding RISC Complex Binding
	Biological Process	Action Potential Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Neurotransmitter Secretion Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Positive Regulation Of Translation ERK1 And ERK2 Cascade CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation
Pathways		Ca2+ activated K+ channels cGMP effects
Drugs		Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine
Diseases
GWAS		Appendicular lean mass ( 33097823) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)	Autism ( 24189344)
Interacting Genes		3 interacting genes: MAL MS4A13 SNCA	18 interacting genes: ARHGAP5 C11orf68 CEBPA ERBB2 FAM9B FOXP1 HID1 HNRNPD NEIL3 PABPC1 PCSK7 PSMG1 RNF10 SNW1 STT3A SYNCRIP WBP4 WNK1
Entrez ID		27345	7812
HPRD ID		05564	15949
Ensembl ID		ENSG00000135643	ENSG00000009307
Uniprot IDs		Q86W47	O75534
PDB IDs		5Y7L 6V22 6V35 9CZH 9CZJ 9CZK 9CZM 9CZO 9CZQ 9D18 9D19	1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?		Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Peptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake MCRD-mediated MRNA Stability Complex RISC Complex Binding Dopamine Uptake Involved In Synaptic Transmission Nuclear-transcribed MRNA Catabolic Process, No-go Decay CRD-mediated MRNA Stability Complex Membrane Raft Distribution Response To Iron(II) Ion Membrane Raft Localization Regulation Of Chaperone-mediated Autophagy Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Protein Localization To Axon Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Catecholamine Uptake Dopamine Uptake Dopamine Biosynthetic Process Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Cellular Respiration Supramolecular Fiber IRES-dependent Viral Translational Initiation CRD-mediated MRNA Stabilization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lipid Binding	MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Catalytic Step 2 Spliceosome Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Cytoplasmic Translation RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Translation MRNA Stabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of MRNA Catabolic Process RNA Stabilization Nucleic Acid Binding RNA Splicing Proteasome Binding Response To Ketone Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Motor Neuron Axon Guidance Nuclear Androgen Receptor Binding MRNA Processing Regulation Of Protein Metabolic Process Regulation Of Biological Quality Nuclear Matrix Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy U2-type Catalytic Step 2 Spliceosome Proteasome Core Complex Assembly Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Protein Localization To Vacuolar Membrane MCM Complex Binding
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