UTP20 and PPP1R26

Number of citations of the paper that reports this interaction (PubMedID 16053918)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		UTP20	PPP1R26
Description		UTP20 small subunit processome component	protein phosphatase 1 regulatory subunit 26
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane 90S Preribosome Preribosome, Small Subunit Precursor Small-subunit Processome	Nucleus Nucleolus
	Molecular Function	RNA Binding Protein Binding	Protein Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Negative Regulation Of Cell Population Proliferation Ribosomal Small Subunit Biogenesis
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Alcohol dependence (age at onset) ( 24962325) Brain structure (hippocampal volume) ( 20197096) Health literacy ( 31250787)
Interacting Genes		73 interacting genes: MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PPP1R26 RNF10	5 interacting genes: HOOK2 PPP1CA RB1 TRIB3 UTP20
Entrez ID		27340	9858
HPRD ID		09928	11099
Ensembl ID		ENSG00000120800	ENSG00000196422
Uniprot IDs		O75691	Q5T8A7
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Extracellular Space Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus	RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Transcription By RNA Polymerase II Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Transcription Corepressor Activity Ubiquitin Protein Ligase Binding Negative Regulation Of Myofibroblast Differentiation Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Cellular Response To Insulin Stimulus Glial Cell Apoptotic Process Response To Insulin Rb-E2F Complex Regulation Of Protein Kinase Activity Regulation Of Centromere Complex Assembly Cellular Response To Peptide Hormone Stimulus Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Regulation Of Kinase Activity Response To Peptide Hormone Chromatin Lock Complex Importin-alpha Family Protein Binding Positive Regulation Of Collagen Fibril Organization Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 90S Preribosome Protein Localization To Perinuclear Region Of Cytoplasm FHF Complex Mitogen-activated Protein Kinase Kinase Binding Ubiquitin-protein Transferase Regulator Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Small Molecule Metabolic Process Preribosome, Small Subunit Precursor Ubiquitin Ligase Activator Activity Negative Regulation Of DNA-templated Transcription Chromosome Organization Negative Regulation Of RNA Biosynthetic Process
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