NPHP3 and ASTE1

		NPHP3	ASTE1
Description		nephrocystin 3	asteroid structure-specific endonuclease 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base
	Molecular Function	Protein Binding	Single-stranded DNA Endodeoxyribonuclease Activity Nuclease Activity DNA Endonuclease Activity Protein Binding Hydrolase Activity 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Kidney Development Heart Looping Atrial Septum Development Lipid Metabolic Process Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Non-motile Cilium Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination
Pathways		Trafficking of myristoylated proteins to the cilium
Drugs
Diseases		Renal-hepatic-pancreatic dysplasia Meckel syndrome (MKS); Meckel-Gruber syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 21102462 27182965) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)	Phenylephrine infusion rate during anesthesia ( 31455332) Restless legs syndrome ( 29029846)
Interacting Genes		3 interacting genes: ATXN1 DYSF NPHP1	1 interacting genes: XRCC4
Entrez ID		27031	28990
HPRD ID		06417	11038
Ensembl ID		ENSG00000113971	ENSG00000034533
Uniprot IDs		Q7Z494	D6RG30 Q2TB18
PDB IDs		5L7K
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining	FHA Domain Binding Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Phospholipid Translocation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Ligase Activity DNA Ligase IV Complex Maintenance Of Animal Organ Identity Ureter Development Ciliary Inversin Compartment Determination Of Digestive Tract Left/right Asymmetry Determination Of Pancreatic Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Atrial Septum Development Positive Regulation Of Phospholipid Transport Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Convergent Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Kidney Morphogenesis Cellular Response To Lithium Ion Regulation Of Plasma Membrane Organization Response To Lithium Ion V(D)J Recombination Regulation Of Non-canonical Wnt Signaling Pathway Protein Localization To Site Of Double-strand Break Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Photoreceptor Cell Maintenance Regulation Of Membrane Lipid Distribution Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cardiac Septum Development Extracellular Transport Ciliary Base Non-motile Cilium Assembly Double-strand Break Repair Via Nonhomologous End Joining Heart Looping Embryonic Heart Tube Morphogenesis Positive Regulation Of Lipid Transport Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Site Of Double-strand Break Lung Development
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