TIMM9 and MGAT2

		TIMM9	MGAT2
Description		translocase of inner mitochondrial membrane 9	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex	Golgi Membrane Golgi Apparatus Golgi Stack Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Membrane Insertase Activity Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity	Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Targeting To Mitochondrion Sensory Perception Of Sound Protein Transport Protein Insertion Into Mitochondrial Inner Membrane	Protein Glycosylation Protein N-linked Glycosylation Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Viral Protein Processing
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial protein degradation	Defective MGAT2 causes CDG-2a Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
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Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Brain morphology (MOSTest) ( 32665545)	Blood protein levels ( 30072576)
Interacting Genes			2 interacting genes: GOLPH3 GOLPH3L
Entrez ID		26520	4247
HPRD ID		09574	04013
Ensembl ID		ENSG00000100575	ENSG00000168282
Uniprot IDs		A0A1W2PQS5 A0A1W2PRH9 G3V502 Q9Y5J7	Q10469
PDB IDs		2BSK 7CGP	5VCM 5VCR 5VCS
Enriched GO Terms of Interacting Partners?		Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Regulation Of Toll Signaling Pathway Protein N-linked Glycosylation Via Asparagine Viral Protein Processing Oligosaccharide Biosynthetic Process Ubiquitin-ubiquitin Ligase Activity	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Protein Targeting Establishment Of Protein Localization To Membrane Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Establishment Of Protein Localization To Organelle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Localization Within Membrane Mitochondrial Intermembrane Space Membrane Organization Post-Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Detection Of Nodal Flow Protein Localization To Plasma Membrane Protein Transport Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Positive Regulation Of Protein Transport Mitochondrial Intermembrane Space Chaperone Complex Regulation Of Protein Secretion Response To Rapamycin Establishment Of Protein Localization Golgi Vesicle Transport TIM22 Mitochondrial Import Inner Membrane Insertion Complex Positive Regulation Of Secretion By Cell Vesicle Organization Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Lipid Binding Golgi Ribbon Formation Cellular Localization Cellular Response To Ether Left/right Axis Specification Protein Transporter Activity Membrane Insertase Activity Regulation Of Protein Transport
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