MGAT2

Name	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Structure
Novel Interactors	2 novel interactors: PKD1L1 TIMM9
Interactors	2 interactors: GOLPH3 GOLPH3L
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi Stack Membrane
	Molecular Function	Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Viral Protein Processing
Pathways	Defective MGAT2 causes CDG-2a Maturation of spike protein Reactions specific to the complex N-glycan synthesis pathway
Diseases	Congenital disorders of glycosylation (CDG) type II
GWAS	Blood protein levels ( 30072576 )
Entrez ID	4247
HPRD ID	04013
Ensembl ID	ENSG00000168282
Uniprot IDs	Q10469
PDB IDs	5VCM 5VCR 5VCS
GO Terms Enriched among Interactors ?	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Protein Targeting Establishment Of Protein Localization To Membrane Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Establishment Of Protein Localization To Organelle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Localization Within Membrane Mitochondrial Intermembrane Space Membrane Organization Post-Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Detection Of Nodal Flow Protein Localization To Plasma Membrane Protein Transport Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Positive Regulation Of Protein Transport Mitochondrial Intermembrane Space Chaperone Complex Regulation Of Protein Secretion Response To Rapamycin Establishment Of Protein Localization Golgi Vesicle Transport TIM22 Mitochondrial Import Inner Membrane Insertion Complex Positive Regulation Of Secretion By Cell Vesicle Organization Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Lipid Binding Golgi Ribbon Formation Cellular Localization Cellular Response To Ether Left/right Axis Specification Protein Transporter Activity Membrane Insertase Activity Regulation Of Protein Transport