NARF and CCDC40

		NARF	CCDC40
Description		nuclear prelamin A recognition factor	coiled-coil domain 40 molecular ruler complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Lamin Filament Nuclear Lamina Nucleoplasm Nucleolus Nuclear Lumen	Extracellular Region Cytoplasm Cilium Axoneme Motile Cilium Cell Projection
	Molecular Function	Lamin Binding	Molecular_function Protein Binding
	Biological Process		Heart Looping Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Regulation Of Cilium Beat Frequency Determination Of Left/right Symmetry Flagellated Sperm Motility Lung Development Axoneme Assembly Determination Of Pancreatic Left/right Asymmetry Inner Dynein Arm Assembly Motile Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Protein Localization To Cilium Axonemal Dynein Complex Assembly Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Change in neurofilament light levels ( 31295725) Glucocorticoid-induced osteonecrosis ( 26265699) Lung function ( 31902109)
Interacting Genes		3 interacting genes: APP LMNA SFRP4	1 interacting genes: APP
Entrez ID		26502	55036
HPRD ID		05637	10976
Ensembl ID		ENSG00000141562	ENSG00000141519
Uniprot IDs		Q9UHQ1	Q4G0X9
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Regulation Of Protein Localization To Nucleus Microtubule-based Process Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Sodium-dependent Phosphate Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Microtubule-based Transport Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Sodium-dependent Phosphate Transport Determination Of Pancreatic Left/right Asymmetry Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Lysosome Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Autophagosome Organization Autophagosome Assembly Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Vacuole Organization Cellular Response To Starvation TSC1-TSC2 Complex Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein-macromolecule Adaptor Activity Positive Regulation Of Pentose-phosphate Shunt Response To Starvation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Lamin Filament Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway
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