FAM162A and PARP14

		FAM162A	PARP14
Description		family with sequence similarity 162 member A	poly(ADP-ribose) polymerase family member 14
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Membrane Mitochondrial Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding NAD+ Binding NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Apoptotic Process Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria	Immune System Process Negative Regulation Of Gene Expression Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of Type II Interferon-mediated Signaling Pathway Protein Poly-ADP-ribosylation Positive Regulation Of Interleukin-4-mediated Signaling Pathway
Pathways			Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Risky sexual behaviors (alcohol dependence interaction) ( 28990359)
Interacting Genes		2 interacting genes: HSP90AA1 UBC	2 interacting genes: GPI PARP10
Entrez ID		26355	54625
HPRD ID		06422	11421
Ensembl ID		ENSG00000114023	ENSG00000173193
Uniprot IDs		Q96A26 Q9H2P1	Q460N5 Q8N546
PDB IDs			3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W 6WE2 6WE3 6WE4 7D2C 7L9Y 7LUN 7R3L
Enriched GO Terms of Interacting Partners?			Nicotinamide Nucleotide Metabolic Process Glucose-6-phosphate Isomerase Activity Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Monosaccharide Binding Maintenance Of Animal Organ Identity Ureter Development Ciliary Inversin Compartment Determination Of Digestive Tract Left/right Asymmetry Determination Of Pancreatic Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Negative Regulation Of Protein K63-linked Ubiquitination NAD+-protein-lysine ADP-ribosyltransferase Activity Fructose 6-phosphate Metabolic Process Carbohydrate Derivative Binding Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Erythrocyte Homeostasis Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Convergent Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Atrial Septum Development Kidney Morphogenesis NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Protein Polyubiquitination Protein Auto-ADP-ribosylation NAD+ Biosynthetic Process Via The Salvage Pathway NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Protein K63-linked Ubiquitination Glycolytic Process Through Glucose-6-phosphate Response To Immobilization Stress Nucleobase-containing Small Molecule Metabolic Process Nucleoside Phosphate Metabolic Process Response To Muscle Stretch Purine-containing Compound Metabolic Process Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Glucose Catabolic Process Canonical Glycolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Protein Polyubiquitination NAD+ Biosynthetic Process Viral Protein Processing Translesion Synthesis Pyridine Nucleotide Biosynthetic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Protein Poly-ADP-ribosylation K63-linked Polyubiquitin Modification-dependent Protein Binding
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