GART and TMPRSS15

		GART	TMPRSS15
Description		phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	transmembrane serine protease 15
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Brush Border Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity ATP Binding Transferase Activity Ligase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Metal Ion Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Brainstem Development Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cerebellum Development Cerebral Cortex Development 'de Novo' AMP Biosynthetic Process Adenine Biosynthetic Process 'de Novo' XMP Biosynthetic Process	Proteolysis
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs		Pemetrexed Glycinamide Ribonucleotide N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acid
Diseases			Enterokinase deficiency
GWAS		Crohn's disease ( 23128233) Educational attainment ( 25201988) Psoriasis ( 25854761)	Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)
Interacting Genes		5 interacting genes: CDC42 KPNA2 OGT PXN TRAF6	1 interacting genes: SPINK1
Entrez ID		2618	5651
HPRD ID		00716	05972
Ensembl ID		ENSG00000159131	ENSG00000154646
Uniprot IDs		P22102 Q59HH3	P98073
PDB IDs		1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 2QK4 2V9Y 4EW1 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2 4ZZ3 5J9F 7JG0 7JG3 7JG4 8FDX 8FDY 8FE0 8FJV 8FJW 8FJX 8FJY 9NX6	4DGJ 6ZOV 7WQX
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Communication Intracellular Signaling Cassette Regulation Of Signaling Myeloid Leukocyte Differentiation Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Cell-cell Junction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Myeloid Cell Differentiation Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Macrophage Activation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cell Surface Receptor Signaling Pathway Via JAK-STAT Mononuclear Cell Differentiation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Host-mediated Perturbation Of Viral Process Cell Surface Receptor Signaling Pathway Via STAT Leukocyte Differentiation GBD Domain Binding Storage Vacuole Type I Interferon Receptor Activity Type I Interferon Binding Interferon Receptor Activity Leading Edge Cell Differentiation Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Response To Virus Positive Regulation Of Cell Population Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Population Proliferation Regulation Of Cell Migration	Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Adenine Biosynthetic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Adenine Metabolic Process
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