PPP1R16B and NFX1

		PPP1R16B	NFX1
Description		protein phosphatase 1 regulatory subunit 16B	nuclear transcription factor, X-box binding 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Endothelial Barrier Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Protein Ubiquitination Negative Regulation Of MHC Class II Biosynthetic Process Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Huntington's disease progression ( 28642124) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656 30285260)	Fasting glucose ( 34059833)
Interacting Genes		37 interacting genes: ATPAF2 CDCA7L CEP55 CEP70 CRX DSCAM DVL2 DVL3 FAM83A FARS2 FLYWCH1 GATA1 GFAP GOLGA2 HAPLN2 HUNK IKZF3 KCTD9 MAGOH MISP NEFL PATZ1 PHC2 PLEKHN1 RBPMS RFC5 SCNM1 SF3B4 SHC3 TACO1 TADA2A TASOR2 TFIP11 TLE5 TXN2 ZNF410 ZNF564	5 interacting genes: ELAVL4 MAML3 UBC UBE2N UBE3A
Entrez ID		26051	4799
HPRD ID		15168	11936
Ensembl ID		ENSG00000101445	ENSG00000086102
Uniprot IDs		Q96T49	Q12986
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Protein Polyubiquitination Post-translational Protein Modification Ligase Inhibitor Activity Negative Regulation Of TORC1 Signaling Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein K63-linked Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of TOR Signaling Pre-mRNA Intronic Pyrimidine-rich Binding Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution UBC13-MMS2 Complex Regulation Of Golgi Lumen Acidification Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus Growth Cone Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Complex Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of TOR Signaling Positive Regulation Of Cellular PH Reduction Mitochondrial Depolarization Oncogene-induced Cell Senescence Negative Regulation Of Immature T Cell Proliferation Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process RNA Binding Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Localization To Lysosome G Protein-coupled Opioid Receptor Activity Myosin Phosphatase Regulator Activity Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Myeloid Cell Apoptotic Process
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