FAM32A and ADAMTS1

		FAM32A	ADAMTS1
Description		family with sequence similarity 32 member A	ADAM metallopeptidase with thrombospondin type 1 motif 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Extracellular Region Basement Membrane Extracellular Matrix Cytoplasmic Vesicle
	Molecular Function	RNA Binding Protein Binding	Metalloendopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Apoptotic Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		mRNA Splicing - Major Pathway	Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: APP CEBPA NSFL1C	9 interacting genes: A2M ACAN CFTR DYRK1A FURIN KRT40 KRTAP10-8 VCAN VEGFA
Entrez ID		26017	9510
HPRD ID		13305	05530
Ensembl ID		ENSG00000105058	ENSG00000154734
Uniprot IDs		Q9Y421	B2RB33 Q9UHI8
PDB IDs		6QDV 7W5A 7W5B 8C6J 9FMD	2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heparin Binding Cellular Response To Metal Ion CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex VCP-NSFL1C Complex Positive Regulation Of Mitotic Centrosome Separation Negative Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Maturation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling White Fat Cell Proliferation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Negative Regulation Of Hematopoietic Stem Cell Proliferation	Extracellular Matrix Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Golgi Lumen Hyaluronic Acid Binding Platelet Alpha Granule Lumen Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Serine-type Endopeptidase Inhibitor Activity Extracellular Space Cell Surface Alpha2-adrenergic Receptor Activity Lysosomal Lumen Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Interphotoreceptor Matrix Histone H3T45 Kinase Activity Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Extracellular Matrix Disassembly Nerve Growth Factor Production Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production Lymph Vessel Morphogenesis Negative Regulation Of Adherens Junction Organization VEGF-A Complex Granulocyte Chemotaxis VEGF-activated Neuropilin Signaling Pathway Vascular Endothelial Growth Factor Receptor 1 Binding Negative Regulation Of Blood-brain Barrier Permeability Granulocyte Migration Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Establishment Of Endothelial Barrier Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Cellular Stress Response To Acid Chemical Coronary Vein Morphogenesis Basophil Chemotaxis Keratin Filament Extracellular Region Protease Binding Positive Regulation Of Enamel Mineralization
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