DNAH1 and SEPSECS

		DNAH1	SEPSECS
Description		dynein axonemal heavy chain 1	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Inner Dynein Arm Cell Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	TRNA Binding RNA Binding Protein Binding Transferase Activity O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Sperm Axoneme Assembly Flagellated Sperm Motility Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility	Selenocysteine Incorporation Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec Translation
Pathways			Selenocysteine synthesis
Drugs			Pyridoxal phosphate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Chronotype ( 30696823) Electroencephalogram traits ( 25387704) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Tonsillectomy ( 27182965 28928442)
Interacting Genes			1 interacting genes: DTX2
Entrez ID		25981	51091
HPRD ID		11790	11561
Ensembl ID		ENSG00000114841	ENSG00000109618
Uniprot IDs		A0A140VJI6 Q9P2D7	A0A7P0TA23 A1A4F3 Q9HD40
PDB IDs		8I3J 8J07	3HL2 4ZDL 4ZDO 4ZDP 7L1T 7MDL 8G9Z
Enriched GO Terms of Interacting Partners?		DNA/RNA Helicase Activity RNA Binding TRNA Processing Growth Plate Cartilage Chondrocyte Development Positive Regulation Of Centrosome Duplication Chondrocyte Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Protein Localization To Chromosome, Telomeric Region O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec MPP7-DLG1-LIN7 Complex	Inner Dynein Arm Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Sperm Axoneme Assembly Dynein Complex Protein K11-linked Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Post-translational Protein Modification Protein Branched Polyubiquitination Protein Ubiquitination Nuclear Periphery Protein Modification By Small Protein Conjugation Anaphase-promoting Complex Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Axoneme Assembly
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